C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: potassium voltage-gated channel, KQT-like subfamily, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000053918 KCNQ1 9606 + 11:2444684-2849109 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000155840 KCNQ1-001 2444991-2849109 protein_coding
  ENST00000335475 KCNQ1-002 2461436-2848238 protein_coding
  ENST00000345015 KCNQ1-004 2445322-2527976 processed_transcript
  ENST00000380776 KCNQ1-006 2461887-2527973 protein_coding
  ENST00000496887 KCNQ1-005 2444684-2572906 protein_coding
  ENST00000526095 KCNQ1-007 2777575-2848511 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000155840ENST00000335475
Transcript ID Adipose Adrenal Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000155840 1.961±0.00 3.863±0.00 2.244±0.00 8.261±0.00 20.970±0.00 0.706±0.00 6.756±0.00 N/A 3.097±1.61 3.221±0.00
ENST00000335475 N/A N/A N/A 4.639±0.00 N/A N/A N/A 9.453±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009BT CIL_0009BT_0001 VISTA 11:2074187-2675527
CIL_0008VI CIL_0008VI_0001 VISTA 11:2150916-2751083
CIL_0008FP CIL_0008FP_0001 VISTA 11:2232763-2834370
CIL_0008A3 CIL_0008A3_0001 VISTA 11:2289701-2893486
CIL_0003FM CIL_0003FM_0002 CGP 11:2444684-2885881

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005249 IDA voltage-gated potassium channel activity
GO:0005251 IDA delayed rectifier potassium channel activity
GO:0005515 IPI protein binding
GO:0005516 IDA calmodulin binding
GO:0005764 IDA lysosome
GO:0005769 IDA early endosome
GO:0005770 IDA late endosome
GO:0005886 TAS plasma membrane
GO:0006349 IEA regulation of gene expression by genetic imprinting
GO:0006811 IEA ion transport
GO:0007268 TAS synaptic transmission
GO:0007605 TAS sensory perception of sound
GO:0008016 IC regulation of heart contraction
GO:0008076 IDA voltage-gated potassium channel complex
GO:0008157 IDA protein phosphatase 1 binding
GO:0016020 IEA membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016458 IEA gene silencing
GO:0034236 IDA protein kinase A catalytic subunit binding
GO:0034237 IDA protein kinase A regulatory subunit binding
GO:0035690 IDA cellular response to drug
GO:0044325 IPI ion channel binding
GO:0055085 IEA transmembrane transport
GO:0060048 IMP cardiac muscle contraction
GO:0060306 IDA regulation of membrane repolarization
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060372 IMP regulation of atrial cardiac muscle cell membrane repolarization
GO:0071320 IDA cellular response to cAMP
GO:0071435 IDA potassium ion export
GO:0071805 IDA potassium ion transmembrane transport
GO:0071872 TAS cellular response to epinephrine stimulus
GO:0072358 IEA cardiovascular system development
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086008 IMP voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086011 IDA membrane repolarization during action potential
GO:0086013 TAS membrane repolarization during cardiac muscle cell action potential
GO:0086014 IMP atrial cardiac muscle cell action potential
GO:0086089 IMP voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:0097110 IPI scaffold protein binding
GO:1901381 IDA positive regulation of potassium ion transmembrane transport
GO:1902282 IMP voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059798 kcnq1 potassium voltage-gated channel, KQT-like subfamily, member 1 protein_coding Danio_rerio
ENSMUSG00000009545 Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 protein_coding Mus_musculus

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