C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Ras protein-specific guanine nucleotide-releasing factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000058335 RASGRF1 9606 - 15:78959947-79090773 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000394745 RASGRF1-003 78961942-79005665 protein_coding
  ENST00000419573 RASGRF1-001 78959947-79090773 protein_coding
  ENST00000558480 RASGRF1-002 78959947-79090764 protein_coding
  ENST00000559926 RASGRF1-009 78971903-78979125 processed_transcript
  ENST00000560286 RASGRF1-008 78980425-78985310 retained_intron
  ENST00000560334 RASGRF1-004 78978380-79064663 processed_transcript
  ENST00000560943 RASGRF1-006 78980657-78998266 retained_intron
  ENST00000561112 RASGRF1-007 78991712-78998071 processed_transcript
  ENST00000623620 RASGRF1-005 78980146-78981666 TEC

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000394745ENST00000419573ENST00000558480ENST00000559926ENST00000560286ENST00000560334ENST00000560943ENST00000623620
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000394745 0.008±0.00 0.250±0.00 0.081±0.00 N/A 0.082±0.00 N/A N/A N/A N/A N/A 0.379±0.00 N/A N/A
ENST00000419573 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.178±0.00 0.048±0.00
ENST00000558480 0.010±0.00 N/A 0.016±0.00 10.749±7.09 N/A 0.150±0.00 0.009±0.00 N/A 0.402±0.00 N/A 0.400±0.00 0.329±0.11 0.070±0.02
ENST00000559926 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.610±0.00 N/A N/A N/A
ENST00000560286 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.803±0.00 N/A N/A
ENST00000560334 0.009±0.00 N/A N/A N/A 0.055±0.00 0.044±0.00 0.018±0.00 N/A N/A 0.014±0.00 0.024±0.00 N/A 0.101±0.00
ENST00000560943 N/A N/A N/A N/A N/A N/A N/A N/A 3.076±0.31 N/A 0.372±0.00 N/A N/A
ENST00000623620 N/A N/A N/A N/A N/A N/A N/A 0.094±0.00 N/A N/A 0.202±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005088 TAS Ras guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005829 ISS cytosol
GO:0005886 NAS plasma membrane
GO:0007165 TAS signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007268 TAS synaptic transmission
GO:0007616 NAS long-term memory
GO:0008283 IEA cell proliferation
GO:0030426 ISS growth cone
GO:0031175 ISS neuron projection development
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0032863 ISS activation of Rac GTPase activity
GO:0035020 ISS regulation of Rac protein signal transduction
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035254 IEA glutamate receptor binding
GO:0043005 NAS neuron projection
GO:0046578 ISS regulation of Ras protein signal transduction
GO:0046579 ISS positive regulation of Ras protein signal transduction
GO:0048167 ISS regulation of synaptic plasticity
GO:0048168 IEA regulation of neuronal synaptic plasticity
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:2000310 IEA regulation of N-methyl-D-aspartate selective glutamate receptor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073824 RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 protein_coding Danio_rerio
ENSMUSG00000032356 Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 protein_coding Mus_musculus

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