C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000064651 SLC12A2 9606 + 5:128083766-128189688 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262461 SLC12A2-001 128083766-128189688 protein_coding
  ENST00000343225 SLC12A2-004 128083848-128188442 protein_coding
  ENST00000502849 SLC12A2-007 128178380-128182921 retained_intron
  ENST00000504416 SLC12A2-002 128157988-128171095 retained_intron
  ENST00000507791 SLC12A2-006 128177549-128184507 processed_transcript
  ENST00000509205 SLC12A2-003 128083791-128187025 nonsense_mediated_decay
  ENST00000509616 SLC12A2-005 128158049-128171882 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262461ENST00000343225ENST00000509205
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262461 9.815±0.00 1.817±0.00 1.143±0.00 10.945±0.00 13.760±6.01 11.214±7.77 2.304±1.20 1.580±1.36 2.188±1.42 2.912±1.58 1.464±1.09 12.888±10.00 1.106±0.44 3.280±0.13
ENST00000343225 N/A N/A N/A 2.587±0.00 N/A N/A 0.382±0.00 N/A N/A 1.351±0.00 N/A N/A N/A N/A
ENST00000509205 N/A N/A 0.707±0.00 4.053±0.00 24.463±0.00 13.544±0.00 1.112±0.09 0.272±0.00 N/A 2.507±1.56 1.993±0.00 N/A N/A 5.574±2.26

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006CW CIL_0006CW_0002 CGP 5:127649044-128189688
CIL_00041L CIL_00041L_0001 CGP 5:128083766-128659185

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006810 TAS:IEA transport
GO:0006811 TAS:IEA ion transport
GO:0006813 IEA potassium ion transport
GO:0006814 IEA sodium ion transport
GO:0006821 IEA chloride transport
GO:0006972 IEA hyperosmotic response
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0008511 IEA sodium:potassium:chloride symporter activity
GO:0008519 IDA ammonium transmembrane transporter activity
GO:0015377 IEA cation:chloride symporter activity
GO:0015696 IDA ammonium transport
GO:0016020 TAS:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0030321 IDA transepithelial chloride transport
GO:0031982 IDA vesicle
GO:0035264 IEA multicellular organism growth
GO:0045795 IEA positive regulation of cell volume
GO:0050910 IEA detection of mechanical stimulus involved in sensory perception of sound
GO:0055085 TAS:IEA transmembrane transport
GO:0060444 IEA branching involved in mammary gland duct morphogenesis
GO:0060763 IEA mammary duct terminal end bud growth
GO:0070062 IDA extracellular vesicular exosome
GO:0070634 IDA transepithelial ammonium transport
GO:0072488 IDA ammonium transmembrane transport
GO:1902476 IEA chloride transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010640 slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 protein_coding Danio_rerio
ENSDARG00000086870 slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 protein_coding Danio_rerio
ENSDARG00000089789 CABZ01084010.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000090924 CABZ01084014.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000091220 SLC12A2 (4 of 5) solute carrier family 12 (sodium/potassium/chloride transporter), member 2 protein_coding Danio_rerio
ENSDARG00000091708 CABZ01084012.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000024597 Slc12a2 solute carrier family 12, member 2 protein_coding Mus_musculus

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