C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065361 ERBB3 9606 + 12:56079857-56103505 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000267101 ERBB3-001 56079861-56103505 protein_coding
  ENST00000411731 ERBB3-006 56080137-56085623 protein_coding
  ENST00000415288 ERBB3-024 56083319-56102336 protein_coding
  ENST00000546748 ERBB3-015 56087824-56088868 retained_intron
  ENST00000546884 ERBB3-022 56080204-56086672 retained_intron
  ENST00000548709 ERBB3-018 56097134-56098980 retained_intron
  ENST00000549061 ERBB3-011 56079857-56086635 protein_coding
  ENST00000549205 ERBB3-016 56093483-56096063 retained_intron
  ENST00000549282 ERBB3-010 56079857-56085139 protein_coding
  ENST00000549472 ERBB3-026 56086519-56088064 retained_intron
  ENST00000549644 ERBB3-017 56094522-56095527 retained_intron
  ENST00000549672 ERBB3-020 56083313-56086631 protein_coding
  ENST00000549832 ERBB3-004 56098251-56103499 protein_coding
  ENST00000550070 ERBB3-009 56093832-56102834 protein_coding
  ENST00000550828 ERBB3-025 56093514-56093992 protein_coding
  ENST00000550869 ERBB3-014 56080167-56096769 nonsense_mediated_decay
  ENST00000551085 ERBB3-023 56080168-56102092 nonsense_mediated_decay
  ENST00000551176 ERBB3-007 56088629-56088996 retained_intron
  ENST00000551242 ERBB3-003 56080205-56102834 nonsense_mediated_decay
  ENST00000552691 ERBB3-019 56099866-56100300 retained_intron
  ENST00000553131 ERBB3-005 56095991-56102806 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonKidneyLiverLungOvaryPlacentaENST00000267101ENST00000415288ENST00000549832ENST00000550070
Transcript ID Bladder Brain Breast Colon Kidney Liver Lung Ovary Placenta
ENST00000267101 N/A 6.632±3.87 5.382±1.58 7.341±0.07 4.725±0.00 4.295±2.53 3.706±1.30 28.779±22.27 7.861±0.58
ENST00000415288 4.799±0.00 N/A 4.043±0.00 6.569±0.00 8.013±0.00 N/A 4.070±0.00 12.312±0.00 N/A
ENST00000549832 N/A N/A 5.205±0.00 N/A N/A 7.834±0.00 N/A 10.507±0.00 N/A
ENST00000550070 N/A N/A N/A N/A N/A N/A N/A 95.955±0.00 11.693±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002TJ CIL_0002TJ_0003 CGP 12:56079857-56109289

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003197 IEA endocardial cushion development
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IEA receptor signaling protein tyrosine kinase activity
GO:0004888 ISS transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007162 IDA negative regulation of cell adhesion
GO:0007165 IDA signal transduction
GO:0007169 ISS:IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007422 ISS peripheral nervous system development
GO:0007507 ISS heart development
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009968 IDA negative regulation of signal transduction
GO:0014037 ISS Schwann cell differentiation
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0014068 TAS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IDA basolateral plasma membrane
GO:0016324 IEA apical plasma membrane
GO:0016328 IEA lateral plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019838 IPI growth factor binding
GO:0021545 ISS cranial nerve development
GO:0030296 IDA protein tyrosine kinase activator activity
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 NAS wound healing
GO:0042127 IDA regulation of cell proliferation
GO:0042802 IPI identical protein binding
GO:0042803 NAS protein homodimerization activity
GO:0043235 IDA receptor complex
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0046982 IDA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0051048 IDA negative regulation of secretion
GO:0051402 IMP neuron apoptotic process
GO:0061098 IMP positive regulation of protein tyrosine kinase activity
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006202 erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a protein_coding Danio_rerio
ENSDARG00000036993 erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b protein_coding Danio_rerio
ENSMUSG00000018166 Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) protein_coding Mus_musculus

Loading