C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ferrochelatase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000066926 FECH 9606 - 18:57548283-57586772 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262093 FECH-001 57548283-57586772 protein_coding
  ENST00000382873 FECH-002 57549510-57586654 protein_coding
  ENST00000585494 FECH-003 57550254-57586701 nonsense_mediated_decay
  ENST00000585699 FECH-004 57566548-57586699 processed_transcript
  ENST00000585747 FECH-006 57567845-57586689 protein_coding
  ENST00000585878 FECH-007 57572990-57586654 retained_intron
  ENST00000591215 FECH-009 57566557-57586612 protein_coding
  ENST00000591977 FECH-010 57551175-57559215 protein_coding
  ENST00000592111 FECH-008 57573005-57586621 retained_intron
  ENST00000592699 FECH-005 57554259-57586690 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262093ENST00000382873ENST00000585494ENST00000585747ENST00000591977ENST00000592699
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262093 1.688±0.00 1.868±0.00 2.904±0.00 1.507±0.92 1.723±0.88 1.271±0.00 0.948±0.00 3.390±2.03 2.389±0.00 1.413±0.00 1.318±0.31 2.130±0.72 1.823±0.88 1.356±0.11
ENST00000382873 2.187±0.00 1.528±0.00 1.588±0.00 2.436±1.54 2.744±0.00 1.392±0.00 2.335±1.83 4.344±2.56 2.773±1.62 1.707±1.39 3.307±0.15 1.817±1.07 3.205±1.50 2.194±0.00
ENST00000585494 N/A N/A N/A 0.768±0.00 N/A N/A N/A N/A N/A N/A 1.284±0.00 N/A N/A N/A
ENST00000585747 N/A N/A N/A 2.684±0.00 3.290±0.00 N/A N/A 3.726±0.00 N/A N/A 8.023±0.00 N/A N/A N/A
ENST00000591977 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.959±0.00 1.565±0.00
ENST00000592699 N/A N/A 5.061±0.00 N/A N/A N/A 1.700±0.00 3.670±0.00 2.477±0.00 1.548±0.00 N/A 1.153±0.00 2.529±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006O8 CIL_0006O8_0001 CGP 18:57435685-57586772
CIL_0006O9 CIL_0006O9_0001 CGP 18:57548283-57622213

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004325 IDA:IEA ferrochelatase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0006091 TAS generation of precursor metabolites and energy
GO:0006778 TAS porphyrin-containing compound metabolic process
GO:0006779 IEA porphyrin-containing compound biosynthetic process
GO:0006783 TAS:IEA heme biosynthetic process
GO:0008198 TAS ferrous iron binding
GO:0008203 IEA cholesterol metabolic process
GO:0009416 TAS response to light stimulus
GO:0009589 IEA detection of UV
GO:0010038 IEA response to metal ion
GO:0010288 IEA response to lead ion
GO:0010468 IEA regulation of gene expression
GO:0010999 IEA regulation of eIF2 alpha phosphorylation by heme
GO:0017085 IEA response to insecticide
GO:0020037 IEA heme binding
GO:0030218 IEA erythrocyte differentiation
GO:0030350 IEA iron-responsive element binding
GO:0034379 IEA very-low-density lipoprotein particle assembly
GO:0042493 IEA response to drug
GO:0044281 TAS small molecule metabolic process
GO:0045471 IEA response to ethanol
GO:0046501 IDA protoporphyrinogen IX metabolic process
GO:0046685 IEA response to arsenic-containing substance
GO:0046906 IEA tetrapyrrole binding
GO:0046984 IEA regulation of hemoglobin biosynthetic process
GO:0051537 IEA 2 iron, 2 sulfur cluster binding
GO:0051597 IEA response to methylmercury
GO:0055072 IEA iron ion homeostasis
GO:0070541 IEA response to platinum ion
GO:0071549 IEA cellular response to dexamethasone stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003462 fech ferrochelatase protein_coding Danio_rerio
ENSMUSG00000024588 Fech ferrochelatase protein_coding Mus_musculus

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