C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase C, zeta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067606 PRKCZ 9606 + 1:2050470-2185395 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000378567 PRKCZ-001 2050470-2185395 protein_coding
  ENST00000400920 PRKCZ-201 2104716-2185393 protein_coding
  ENST00000400921 PRKCZ-009 2073462-2185390 protein_coding
  ENST00000419838 PRKCZ-027 2135262-2150865 processed_transcript
  ENST00000461106 PRKCZ-015 2073986-2185190 protein_coding
  ENST00000461465 PRKCZ-016 2074688-2150836 protein_coding
  ENST00000466352 PRKCZ-006 2134813-2146098 protein_coding
  ENST00000466651 PRKCZ-014 2055679-2135347 processed_transcript
  ENST00000468310 PRKCZ-007 2050485-2146108 protein_coding
  ENST00000470511 PRKCZ-021 2116205-2150897 protein_coding
  ENST00000470596 PRKCZ-017 2074855-2150945 protein_coding
  ENST00000470986 PRKCZ-010 2111654-2150978 protein_coding
  ENST00000471018 PRKCZ-004 2133638-2148924 protein_coding
  ENST00000472017 PRKCZ-023 2168975-2173951 processed_transcript
  ENST00000478770 PRKCZ-012 2145387-2185116 nonsense_mediated_decay
  ENST00000479263 PRKCZ-002 2144451-2185395 processed_transcript
  ENST00000479566 PRKCZ-008 2055441-2071536 processed_transcript
  ENST00000481140 PRKCZ-019 2082248-2150936 nonsense_mediated_decay
  ENST00000482686 PRKCZ-003 2104716-2150870 protein_coding
  ENST00000484419 PRKCZ-013 2050503-2055760 retained_intron
  ENST00000486681 PRKCZ-022 2104739-2156087 protein_coding
  ENST00000495347 PRKCZ-020 2073719-2146086 protein_coding
  ENST00000496325 PRKCZ-018 2075244-2150863 protein_coding
  ENST00000497183 PRKCZ-011 2134990-2150979 protein_coding
  ENST00000503297 PRKCZ-026 2050808-2059591 protein_coding
  ENST00000503672 PRKCZ-024 2145357-2156728 retained_intron
  ENST00000505322 PRKCZ-025 2168848-2185393 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378567ENST00000400920ENST00000400921ENST00000461106ENST00000461465ENST00000470511ENST00000470986ENST00000472017ENST00000478770ENST00000479263
Transcript ID Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378567 N/A 0.938±0.00 1.800±0.00 2.064±1.70 1.271±0.00 1.158±0.89 7.327±2.68 N/A 5.279±0.16 N/A N/A
ENST00000400920 N/A N/A N/A N/A N/A N/A N/A N/A 3.349±0.00 20.698±3.43 N/A
ENST00000400921 9.554±0.00 N/A N/A N/A N/A N/A N/A N/A 1.403±0.00 N/A N/A
ENST00000461106 N/A N/A N/A 1.377±1.21 N/A 1.791±0.00 N/A N/A N/A N/A N/A
ENST00000461465 N/A N/A N/A 1.096±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000470511 N/A N/A 5.437±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000470986 N/A N/A N/A N/A N/A N/A N/A N/A 41.259±0.00 N/A 45.193±0.00
ENST00000472017 N/A N/A N/A N/A N/A N/A N/A 0.153±0.00 N/A N/A N/A
ENST00000478770 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.424±0.00
ENST00000479263 N/A N/A N/A N/A 1.439±0.00 N/A N/A N/A 20.337±0.00 11.122±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QV CIL_0007QV_0001 VISTA 1:1910870-2513425

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IEA microtubule cytoskeleton organization
GO:0001954 IEA positive regulation of cell-matrix adhesion
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004697 IEA protein kinase C activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005635 IEA nuclear envelope
GO:0005737 TAS cytoplasm
GO:0005768 IEA endosome
GO:0005815 IEA microtubule organizing center
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005923 IEA tight junction
GO:0005938 IEA cell cortex
GO:0006468 IDA:IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 TAS signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0007616 IEA long-term memory
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008286 IEA insulin receptor signaling pathway
GO:0015459 IEA potassium channel regulator activity
GO:0016020 TAS membrane
GO:0016324 IEA apical plasma membrane
GO:0016363 IEA nuclear matrix
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0030010 ISS establishment of cell polarity
GO:0030054 TAS cell junction
GO:0030168 TAS platelet activation
GO:0031252 IEA cell leading edge
GO:0031333 IMP negative regulation of protein complex assembly
GO:0031532 IEA actin cytoskeleton reorganization
GO:0031584 IEA activation of phospholipase D activity
GO:0031941 IEA filamentous actin
GO:0032148 IEA activation of protein kinase B activity
GO:0032753 ISS positive regulation of interleukin-4 production
GO:0032869 IEA cellular response to insulin stimulus
GO:0034613 IEA cellular protein localization
GO:0035556 IEA intracellular signal transduction
GO:0035748 IEA myelin sheath abaxonal region
GO:0043066 IEA negative regulation of apoptotic process
GO:0043203 IEA axon hillock
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043274 IEA phospholipase binding
GO:0043560 IC insulin receptor substrate binding
GO:0045121 IEA membrane raft
GO:0045179 IEA apical cortex
GO:0045630 ISS positive regulation of T-helper 2 cell differentiation
GO:0046326 IEA positive regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0046628 ISS positive regulation of insulin receptor signaling pathway
GO:0046872 IEA metal ion binding
GO:0047496 IEA vesicle transport along microtubule
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050732 IMP negative regulation of peptidyl-tyrosine phosphorylation
GO:0050806 IEA positive regulation of synaptic transmission
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051222 IEA positive regulation of protein transport
GO:0051291 IEA protein heterooligomerization
GO:0051346 IEA negative regulation of hydrolase activity
GO:0051899 IEA membrane depolarization
GO:0060081 IEA membrane hyperpolarization
GO:0060291 ISS long-term synaptic potentiation
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070528 IEA protein kinase C signaling
GO:0071889 IEA 14-3-3 protein binding
GO:0072659 IEA protein localization to plasma membrane
GO:1990138 IEA neuron projection extension
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000553 ISS positive regulation of T-helper 2 cell cytokine production
GO:2000664 ISS positive regulation of interleukin-5 secretion
GO:2000667 ISS positive regulation of interleukin-13 secretion
GO:2001181 ISS positive regulation of interleukin-10 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043332 prkcz protein kinase C, zeta protein_coding Danio_rerio
ENSMUSG00000029053 Prkcz protein kinase C, zeta protein_coding Mus_musculus

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