C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocyte enhancer factor 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068305 MEF2A 9606 + 15:99565417-99716466 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338042 MEF2A-201 99565928-99716422 protein_coding
  ENST00000354410 MEF2A-001 99565700-99716466 protein_coding
  ENST00000449277 MEF2A-004 99565990-99716406 protein_coding
  ENST00000557785 MEF2A-002 99565980-99713782 protein_coding
  ENST00000557942 MEF2A-005 99566087-99716424 protein_coding
  ENST00000558049 MEF2A-010 99565987-99645621 protein_coding
  ENST00000558812 MEF2A-003 99565928-99713324 protein_coding
  ENST00000558856 MEF2A-011 99565928-99657531 processed_transcript
  ENST00000558983 MEF2A-012 99565980-99671562 retained_intron
  ENST00000559036 MEF2A-006 99565969-99645831 retained_intron
  ENST00000559903 MEF2A-009 99566483-99645739 protein_coding
  ENST00000560493 MEF2A-008 99565417-99645761 protein_coding
  ENST00000561125 MEF2A-007 99706595-99715962 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338042ENST00000354410ENST00000449277ENST00000557785ENST00000557942
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338042 5.489±0.00 N/A 3.024±0.00 3.032±0.93 3.751±1.31 N/A 2.827±0.00 3.121±1.95 5.490±0.00 N/A 3.362±1.20 5.055±0.67 6.132±0.00
ENST00000354410 2.278±0.00 N/A 2.939±0.00 2.401±0.00 2.385±0.78 N/A 1.595±0.00 2.146±1.38 4.725±0.00 1.479±0.00 1.723±0.00 N/A N/A
ENST00000449277 N/A N/A N/A 2.027±0.00 N/A N/A N/A 1.625±0.00 N/A N/A 2.777±0.00 N/A N/A
ENST00000557785 3.503±0.00 2.924±0.00 5.559±0.00 5.217±0.00 3.616±0.00 7.303±0.00 3.764±0.00 8.416±0.00 N/A 2.214±0.00 4.955±0.00 N/A N/A
ENST00000557942 N/A 1.997±0.00 8.227±0.00 1.611±0.00 N/A 5.974±0.00 N/A N/A N/A 1.527±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00079Q CIL_00079Q_0002 CGP 15:99251362-99716466

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000002 ISS mitochondrial genome maintenance
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IDA MAPK cascade
GO:0000790 ISS nuclear chromatin
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006351 IDA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006915 IEA apoptotic process
GO:0007507 IEP heart development
GO:0007517 NAS muscle organ development
GO:0019901 IEA protein kinase binding
GO:0033613 IPI activating transcription factor binding
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035035 IPI histone acetyltransferase binding
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042692 TAS muscle cell differentiation
GO:0042826 IPI histone deacetylase binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045087 TAS innate immune response
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048311 ISS mitochondrion distribution
GO:0048813 ISS dendrite morphogenesis
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0055005 ISS ventricular cardiac myofibril assembly
GO:0061337 ISS cardiac conduction
GO:0070375 IMP ERK5 cascade
GO:0071277 IDA cellular response to calcium ion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031756 mef2aa myocyte enhancer factor 2aa protein_coding Danio_rerio
ENSDARG00000057527 MEF2A (2 of 2) myocyte enhancer factor 2A protein_coding Danio_rerio
ENSMUSG00000030557 Mef2a myocyte enhancer factor 2A protein_coding Mus_musculus

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