C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocyte enhancer factor 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030557 Mef2a 10090 - 7:67231163-67372858 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032776 Mef2a-005 67234207-67372858 protein_coding
  ENSMUST00000072460 Mef2a-001 67234147-67372858 nonsense_mediated_decay
  ENSMUST00000076325 Mef2a-003 67234039-67372858 protein_coding
  ENSMUST00000107476 Mef2a-004 67231918-67372858 protein_coding
  ENSMUST00000133074 Mef2a-006 67251809-67372858 protein_coding
  ENSMUST00000135493 Mef2a-007 67232084-67316920 nonsense_mediated_decay
  ENSMUST00000144057 Mef2a-008 67349409-67372827 processed_transcript
  ENSMUST00000156690 Mef2a-002 67231163-67372858 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032776ENSMUST00000076325ENSMUST00000107476ENSMUST00000133074ENSMUST00000135493ENSMUST00000156690
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032776 3.746±0.04 2.490±0.00 N/A 6.635±0.00 4.430±0.92 N/A 8.466±1.24 2.852±0.72 0.991±0.00 7.614±0.00 N/A 7.760±2.09 5.392±1.56 2.821±0.40
ENSMUST00000076325 N/A N/A N/A N/A N/A 1.771±0.00 N/A N/A N/A N/A N/A 7.754±0.00 N/A N/A
ENSMUST00000107476 13.467±6.80 13.988±1.18 4.516±0.51 3.643±0.96 10.094±3.04 7.793±1.65 9.100±2.45 5.715±2.48 2.767±1.40 26.186±2.31 N/A 19.123±5.95 3.137±1.14 3.414±1.87
ENSMUST00000133074 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.844±0.00 N/A 8.283±0.00
ENSMUST00000135493 N/A N/A N/A N/A N/A 2.101±0.07 8.569±0.00 N/A N/A N/A N/A N/A N/A 3.110±0.64
ENSMUST00000156690 2.484±0.40 N/A 11.902±1.61 9.854±3.66 3.585±1.50 0.964±0.06 14.795±3.38 2.142±0.01 1.497±0.87 7.198±1.77 11.769±1.08 N/A 4.370±1.43 1.028±0.20

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000002 IMP mitochondrial genome maintenance
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000165 ISS MAPK cascade
GO:0000790 IDA nuclear chromatin
GO:0000977 ISS RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IC RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001105 IEA RNA polymerase II transcription coactivator activity
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006915 IEA apoptotic process
GO:0007399 IEA nervous system development
GO:0007507 IEA heart development
GO:0019901 IPI protein kinase binding
GO:0033613 IPI activating transcription factor binding
GO:0035035 ISS histone acetyltransferase binding
GO:0042826 ISS histone deacetylase binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 ISS SMAD binding
GO:0046982 IEA protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048311 IMP mitochondrion distribution
GO:0055005 IMP ventricular cardiac myofibril assembly
GO:0061337 IMP cardiac conduction
GO:0070375 ISS ERK5 cascade
GO:0071277 ISS cellular response to calcium ion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031756 mef2aa myocyte enhancer factor 2aa protein_coding Danio_rerio
ENSDARG00000057527 MEF2A (2 of 2) myocyte enhancer factor 2A protein_coding Danio_rerio
ENSG00000068305 MEF2A myocyte enhancer factor 2A protein_coding Homo_sapiens

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