C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) activator subunit 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000068878 PSME4 9606 - 2:53864067-53970840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000389993 PSME4-002 53864434-53970840 nonsense_mediated_decay
  ENST00000404125 PSME4-001 53864067-53970840 protein_coding
  ENST00000461810 PSME4-008 53907973-53908843 retained_intron
  ENST00000466539 PSME4-010 53866148-53881508 processed_transcript
  ENST00000475694 PSME4-007 53932056-53933169 retained_intron
  ENST00000476586 PSME4-004 53864861-53887316 processed_transcript
  ENST00000478731 PSME4-009 53887417-53888320 retained_intron
  ENST00000481518 PSME4-006 53936095-53970778 processed_transcript
  ENST00000488687 PSME4-005 53864870-53870960 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000389993ENST00000404125ENST00000476586ENST00000488687
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000389993 3.157±0.00 N/A 1.027±0.00 0.641±0.00 3.105±0.00 1.661±0.00 3.611±2.20 N/A 1.191±0.00 1.870±0.00 5.279±0.00 3.124±0.00 0.803±0.00 5.728±0.00
ENST00000404125 2.579±0.00 2.371±0.00 N/A 2.170±1.56 3.430±0.76 3.076±0.00 7.765±5.69 3.679±0.12 3.296±1.49 3.723±0.00 8.732±5.13 4.387±1.20 2.051±0.34 11.275±0.00
ENST00000476586 5.592±0.00 11.504±0.00 N/A N/A 10.144±0.00 6.366±0.00 N/A 9.743±0.00 10.730±0.00 11.418±0.00 21.772±0.00 13.875±2.64 5.414±0.51 19.907±0.00
ENST00000488687 N/A 3.643±0.00 N/A N/A N/A N/A N/A N/A N/A 2.623±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005488 IEA binding
GO:0005634 ISS nucleus
GO:0005829 ISS cytosol
GO:0006281 ISS DNA repair
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007275 IEA multicellular organismal development
GO:0010467 TAS gene expression
GO:0010499 ISS proteasomal ubiquitin-independent protein catabolic process
GO:0010952 IEA positive regulation of peptidase activity
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016504 ISS peptidase activator activity
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035093 ISS spermatogenesis, exchange of chromosomal proteins
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070577 ISS lysine-acetylated histone binding
GO:1990111 ISS spermatoproteasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018742 psme4b proteasome (prosome, macropain) activator subunit 4b protein_coding Danio_rerio
ENSDARG00000069346 psme4a proteasome (prosome, macropain) activator subunit 4a protein_coding Danio_rerio
ENSDARG00000087911 PSME4 (3 of 4) proteasome (prosome, macropain) activator subunit 4 protein_coding Danio_rerio
ENSDARG00000088684 BX663524.3 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000040850 Psme4 proteasome (prosome, macropain) activator subunit 4 protein_coding Mus_musculus

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