C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000069869 NEDD4 9606 - 15:55826922-55993746 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338963 NEDD4-001 55826922-55917131 protein_coding
  ENST00000435532 NEDD4-006 55826922-55993746 protein_coding
  ENST00000502612 NEDD4-009 55860715-55993548 nonsense_mediated_decay
  ENST00000503468 NEDD4-005 55826922-55916469 nonsense_mediated_decay
  ENST00000506154 NEDD4-003 55827335-55917108 protein_coding
  ENST00000507063 NEDD4-007 55862988-55951400 nonsense_mediated_decay
  ENST00000508075 NEDD4-010 55987209-55993602 processed_transcript
  ENST00000508342 NEDD4-002 55826922-55917131 protein_coding
  ENST00000508871 NEDD4-004 55826922-55915654 protein_coding
  ENST00000513957 NEDD4-008 55924363-55966546 retained_intron
  ENST00000514893 NEDD4-011 55862983-55952745 processed_transcript
  ENST00000557845 NEDD4-012 55987731-55993613 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000435532ENST00000503468ENST00000506154ENST00000508075ENST00000508342ENST00000508871
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000435532 3.335±0.00 1.719±0.00 1.666±0.00 0.506±0.00 2.060±0.96 0.923±0.10 1.064±0.23 2.007±0.59 3.701±0.00 3.183±1.60 4.848±0.00 2.337±1.32 1.961±0.88 1.335±0.17
ENST00000503468 N/A N/A N/A N/A N/A 0.598±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000506154 N/A N/A 0.679±0.00 N/A 0.320±0.00 N/A N/A N/A N/A N/A 7.708±0.00 0.935±0.00 N/A N/A
ENST00000508075 N/A 1.852±0.00 10.903±0.00 6.889±5.43 25.462±0.00 16.837±0.00 14.160±0.00 13.301±0.00 20.473±0.00 30.594±0.00 N/A 12.316±5.90 6.424±2.41 18.359±0.00
ENST00000508342 N/A N/A N/A N/A N/A N/A 0.657±0.00 N/A 1.135±0.00 N/A 7.509±0.00 N/A N/A N/A
ENST00000508871 N/A N/A N/A N/A N/A N/A 0.285±0.00 1.310±0.00 N/A N/A 5.996±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000151 ISS ubiquitin ligase complex
GO:0000785 IDA chromatin
GO:0002250 IEA adaptive immune response
GO:0003151 IEA outflow tract morphogenesis
GO:0003197 IEA endocardial cushion development
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 ISS cytosol
GO:0005886 IMP plasma membrane
GO:0005938 IDA cell cortex
GO:0006513 IEA protein monoubiquitination
GO:0006622 IDA protein targeting to lysosome
GO:0007041 IDA lysosomal transport
GO:0007528 IEA neuromuscular junction development
GO:0010766 IDA negative regulation of sodium ion transport
GO:0010768 IMP negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016327 TAS apicolateral plasma membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019089 IMP transmission of virus
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019871 IDA sodium channel inhibitor activity
GO:0019904 IPI protein domain specific binding
GO:0030948 ISS negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 IEP neuron projection development
GO:0031623 IDA receptor internalization
GO:0031698 IDA beta-2 adrenergic receptor binding
GO:0032801 IDA receptor catabolic process
GO:0034644 IMP cellular response to UV
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042110 IEA T cell activation
GO:0042391 IDA regulation of membrane potential
GO:0042787 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 IDA glucocorticoid receptor signaling pathway
GO:0043130 IDA ubiquitin binding
GO:0043162 IMP ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 IMP development involved in symbiotic interaction
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046824 IDA positive regulation of nucleocytoplasmic transport
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048514 IEA blood vessel morphogenesis
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050807 IEA regulation of synapse organization
GO:0050815 ISS phosphoserine binding
GO:0050816 ISS phosphothreonine binding
GO:0050847 IDA progesterone receptor signaling pathway
GO:0051592 TAS response to calcium ion
GO:0070062 IDA extracellular vesicular exosome
GO:0070063 IPI RNA polymerase binding
GO:0070064 IPI proline-rich region binding
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039778 NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000032216 Nedd4 neural precursor cell expressed, developmentally down-regulated 4 protein_coding Mus_musculus

Loading