C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000508342 NEDD4-002 ENSG00000069869 9606 - 15:55826922-55917131 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLiverMuscleENST00000508342
Transcript ID Heart Liver Muscle
ENST00000508342 0.657±0.00 1.135±0.00 7.509±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000151 ISS ubiquitin ligase complex
GO:0000785 IDA chromatin
GO:0002250 IEA adaptive immune response
GO:0003151 IEA outflow tract morphogenesis
GO:0003197 IEA endocardial cushion development
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 ISS cytosol
GO:0005886 IMP plasma membrane
GO:0005938 IDA cell cortex
GO:0006513 IEA protein monoubiquitination
GO:0006622 IDA protein targeting to lysosome
GO:0007041 IDA lysosomal transport
GO:0007528 IEA neuromuscular junction development
GO:0010766 IDA negative regulation of sodium ion transport
GO:0010768 IMP negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016327 TAS apicolateral plasma membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019089 IMP transmission of virus
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019871 IDA sodium channel inhibitor activity
GO:0019904 IPI protein domain specific binding
GO:0030948 ISS negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 IEP neuron projection development
GO:0031623 IDA receptor internalization
GO:0031698 IDA beta-2 adrenergic receptor binding
GO:0032801 IDA receptor catabolic process
GO:0034644 IMP cellular response to UV
GO:0034765 IDA regulation of ion transmembrane transport
GO:0042110 IEA T cell activation
GO:0042391 IDA regulation of membrane potential
GO:0042787 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 IDA glucocorticoid receptor signaling pathway
GO:0043130 IDA ubiquitin binding
GO:0043162 IMP ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 IMP development involved in symbiotic interaction
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046824 IDA positive regulation of nucleocytoplasmic transport
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048514 IEA blood vessel morphogenesis
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050807 IEA regulation of synapse organization
GO:0050815 ISS phosphoserine binding
GO:0050816 ISS phosphothreonine binding
GO:0050847 IDA progesterone receptor signaling pathway
GO:0051592 TAS response to calcium ion
GO:0070062 IDA extracellular vesicular exosome
GO:0070063 IPI RNA polymerase binding
GO:0070064 IPI proline-rich region binding
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IDA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034740 Nedd4-001 protein_coding Mus_musculus 0 1526
ENSMUST00000184333 Nedd4-002 protein_coding Mus_musculus 0 536
ENSMUST00000184450 Nedd4-005 protein_coding Mus_musculus 0 536
ENSMUST00000183375 Nedd4-006 protein_coding Mus_musculus 0 270

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