C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neural precursor cell expressed, developmentally down-regulated 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032216 Nedd4 10090 + 9:72662346-72749852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034740 Nedd4-001 72662346-72749852 protein_coding
  ENSMUST00000183375 Nedd4-006 72662487-72712229 protein_coding
  ENSMUST00000183451 Nedd4-008 72741444-72747153 retained_intron
  ENSMUST00000184020 Nedd4-007 72739472-72748158 nonsense_mediated_decay
  ENSMUST00000184180 Nedd4-010 72668669-72672129 retained_intron
  ENSMUST00000184287 Nedd4-009 72745839-72747263 retained_intron
  ENSMUST00000184333 Nedd4-002 72668680-72720355 protein_coding
  ENSMUST00000184386 Nedd4-003 72662490-72663299 processed_transcript
  ENSMUST00000184450 Nedd4-005 72662482-72720790 protein_coding
  ENSMUST00000184737 Nedd4-004 72662438-72672148 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034740ENSMUST00000184020ENSMUST00000184737
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034740 181.114±30.49 59.365±14.24 149.802±35.64 131.191±33.03 115.933±21.39 54.665±5.58 77.101±6.68 61.688±7.78 49.265±20.59 88.878±9.83 63.537±6.82 174.974±53.95 104.565±13.62 13.525±2.06
ENSMUST00000184020 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 92.690±0.00 N/A N/A
ENSMUST00000184737 N/A 174.346±28.63 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004U3 CIL_0004U3_0002 CGP 9:72662346-72917291

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000151 IPI ubiquitin ligase complex
GO:0000785 IEA chromatin
GO:0002250 IMP adaptive immune response
GO:0003151 IGI outflow tract morphogenesis
GO:0003197 IGI endocardial cushion development
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0005938 IEA cell cortex
GO:0006513 IDA protein monoubiquitination
GO:0006622 IEA protein targeting to lysosome
GO:0007041 IEA lysosomal transport
GO:0007528 IMP neuromuscular junction development
GO:0010766 IDA negative regulation of sodium ion transport
GO:0010768 IEA negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019089 IEA transmission of virus
GO:0019871 IDA sodium channel inhibitor activity
GO:0019904 IEA protein domain specific binding
GO:0030948 IDA negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 IEA neuron projection development
GO:0031623 IEA receptor internalization
GO:0031698 IEA beta-2 adrenergic receptor binding
GO:0032801 IEA receptor catabolic process
GO:0034644 IEA cellular response to UV
GO:0034765 IEA regulation of ion transmembrane transport
GO:0042110 IMP T cell activation
GO:0042391 IEA regulation of membrane potential
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 IEA glucocorticoid receptor signaling pathway
GO:0043130 IEA ubiquitin binding
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 IEA development involved in symbiotic interaction
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046824 IEA positive regulation of nucleocytoplasmic transport
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048514 IGI blood vessel morphogenesis
GO:0048814 IMP regulation of dendrite morphogenesis
GO:0050807 IMP regulation of synapse organization
GO:0050815 IDA phosphoserine binding
GO:0050816 IDA phosphothreonine binding
GO:0050847 IEA progesterone receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070063 IEA RNA polymerase binding
GO:0070064 IPI proline-rich region binding
GO:0070534 ISS protein K63-linked ubiquitination
GO:1901016 IEA regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039778 NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000069869 NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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