C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000071242 RPS6KA2 9606 - 6:166409364-166906451 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265678 RPS6KA2-001 166409364-166627243 protein_coding
  ENST00000366865 RPS6KA2-002 166475726-166510310 processed_transcript
  ENST00000405189 RPS6KA2-007 166412748-166542450 protein_coding
  ENST00000481261 RPS6KA2-006 166412659-166544690 protein_coding
  ENST00000491836 RPS6KA2-004 166439889-166459551 processed_transcript
  ENST00000503859 RPS6KA2-003 166411232-166862551 protein_coding
  ENST00000506565 RPS6KA2-009 166508223-166862670 protein_coding
  ENST00000507350 RPS6KA2-013 166498611-166627522 protein_coding
  ENST00000507371 RPS6KA2-011 166504599-166757911 protein_coding
  ENST00000509742 RPS6KA2-008 166412296-166423984 processed_transcript
  ENST00000510118 RPS6KA2-005 166409388-166862511 protein_coding
  ENST00000511034 RPS6KA2-012 166510280-166627972 protein_coding
  ENST00000512860 RPS6KA2-010 166504515-166906451 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265678ENST00000503859ENST00000507350ENST00000510118
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265678 20.367±0.00 1.231±0.00 11.078±8.65 6.497±3.78 3.869±2.94 14.530±12.23 6.667±4.78 2.649±0.00 16.944±11.66 3.516±1.38 6.814±2.74 4.518±2.67 3.212±0.39
ENST00000503859 N/A N/A N/A N/A N/A N/A N/A 1.884±0.00 N/A N/A N/A N/A 1.766±0.00
ENST00000507350 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.360±0.00 N/A N/A N/A
ENST00000510118 N/A N/A 3.308±0.00 N/A 0.905±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094V CIL_00094V_0001 VISTA 6:166171962-166774036
CIL_0002QE CIL_0002QE_0002 CGP 6:166409364-166956124

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001556 IEA oocyte maturation
GO:0002035 IEA brain renin-angiotensin system
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 TAS:IEA protein serine/threonine kinase activity
GO:0004711 IEA ribosomal protein S6 kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005819 IEA spindle
GO:0005829 TAS cytosol
GO:0005840 IEA ribosome
GO:0006468 IEA protein phosphorylation
GO:0007165 NAS signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0007507 IEA heart development
GO:0008285 IDA negative regulation of cell proliferation
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010628 IEA positive regulation of gene expression
GO:0010659 IEA cardiac muscle cell apoptotic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0031965 IDA nuclear membrane
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 TAS:IEA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065 IDA positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045786 IDA negative regulation of cell cycle
GO:0045835 IEA negative regulation of meiosis
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051403 TAS stress-activated MAPK cascade
GO:0060047 IEA heart contraction
GO:0070613 IEA regulation of protein processing
GO:0071322 IEA cellular response to carbohydrate stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028469 RPS6KA2 Ribosomal protein S6 kinase protein_coding Danio_rerio
ENSMUSG00000023809 Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 protein_coding Mus_musculus

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