C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol binding clathrin assembly protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000073921 PICALM 9606 - 11:85957684-86069882 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356360 PICALM-006 85958987-86068780 protein_coding
  ENST00000393346 PICALM-005 85958814-86068929 protein_coding
  ENST00000525162 PICALM-008 86012343-86069539 protein_coding
  ENST00000526033 PICALM-001 85957688-86069097 protein_coding
  ENST00000526548 PICALM-022 85958811-85977005 retained_intron
  ENST00000526907 PICALM-024 85974782-85978715 retained_intron
  ENST00000526961 PICALM-019 85959037-85996929 protein_coding
  ENST00000528256 PICALM-010 86014870-86069081 protein_coding
  ENST00000528398 PICALM-003 85958839-86069882 protein_coding
  ENST00000528411 PICALM-009 86022378-86069311 processed_transcript
  ENST00000529016 PICALM-023 85959023-86001141 protein_coding
  ENST00000529760 PICALM-018 85958818-86001158 protein_coding
  ENST00000530542 PICALM-017 85976649-86001158 protein_coding
  ENST00000530692 PICALM-021 85958755-85990258 protein_coding
  ENST00000531558 PICALM-012 86011112-86068984 nonsense_mediated_decay
  ENST00000531771 PICALM-014 86007369-86022469 retained_intron
  ENST00000531930 PICALM-007 86012281-86069811 protein_coding
  ENST00000532041 PICALM-011 86012329-86068945 nonsense_mediated_decay
  ENST00000532317 PICALM-002 85957684-86069059 protein_coding
  ENST00000532603 PICALM-020 85958883-85983900 protein_coding
  ENST00000533350 PICALM-015 86001031-86003778 retained_intron
  ENST00000534375 PICALM-016 85981184-85982185 retained_intron
  ENST00000534412 PICALM-013 86000681-86068797 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000393346ENST00000526033ENST00000528256ENST00000529016ENST00000532317
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000393346 N/A N/A N/A N/A N/A N/A N/A 2.726±0.00 N/A 6.503±0.00 N/A N/A N/A N/A
ENST00000526033 N/A N/A N/A N/A N/A N/A 2.161±0.00 N/A 5.377±0.00 N/A N/A N/A N/A 11.401±0.00
ENST00000528256 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.555±0.00 45.700±0.00 92.188±0.00 53.021±0.00
ENST00000529016 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.692±0.00 N/A N/A N/A
ENST00000532317 31.553±0.00 29.733±0.00 9.874±0.00 14.699±0.00 29.075±16.44 16.574±10.71 10.088±7.86 17.877±12.07 13.269±0.77 29.305±19.76 8.110±0.00 15.126±6.75 38.298±13.97 20.824±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005543 IEA phospholipid binding
GO:0005545 IEA:ISS 1-phosphatidylinositol binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005794 IEA Golgi apparatus
GO:0005905 ISS coated pit
GO:0006461 TAS protein complex assembly
GO:0006898 ISS receptor-mediated endocytosis
GO:0007409 IEA axonogenesis
GO:0008283 IMP cell proliferation
GO:0010629 IMP negative regulation of gene expression
GO:0016020 IDA membrane
GO:0016188 ISS synaptic vesicle maturation
GO:0016192 TAS vesicle-mediated transport
GO:0016197 IMP endosomal transport
GO:0030097 IEA hemopoiesis
GO:0030100 IMP regulation of endocytosis
GO:0030118 IEA clathrin coat
GO:0030122 IDA AP-2 adaptor complex
GO:0030132 IDA clathrin coat of coated pit
GO:0030276 IEA:ISS clathrin binding
GO:0031623 IMP receptor internalization
GO:0031982 ISS vesicle
GO:0032050 IDA clathrin heavy chain binding
GO:0032880 IDA regulation of protein localization
GO:0035459 IMP cargo loading into vesicle
GO:0035615 IMP clathrin adaptor activity
GO:0042734 ISS presynaptic membrane
GO:0043025 IDA neuronal cell body
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045211 ISS postsynaptic membrane
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0048261 IDA negative regulation of receptor-mediated endocytosis
GO:0048268 IEA:IMP clathrin coat assembly
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048813 IEA dendrite morphogenesis
GO:0055072 IMP iron ion homeostasis
GO:0072583 IMP clathrin-mediated endocytosis
GO:0097418 IMP neurofibrillary tangle
GO:0097459 IMP iron ion import into cell
GO:1901216 IMP positive regulation of neuron death
GO:1902004 IMP positive regulation of beta-amyloid formation
GO:1902959 IMP regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 ISS positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 ISS negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012866 picalma phosphatidylinositol binding clathrin assembly protein a protein_coding Danio_rerio
ENSDARG00000014137 picalmb phosphatidylinositol binding clathrin assembly protein b protein_coding Danio_rerio
ENSMUSG00000039361 Picalm phosphatidylinositol binding clathrin assembly protein protein_coding Mus_musculus

Loading