C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol binding clathrin assembly protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000526033 PICALM-001 ENSG00000073921 9606 - 11:85957688-86069097 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLiverTestisENST00000526033
Transcript ID Heart Liver Testis
ENST00000526033 2.161±0.00 5.377±0.00 11.401±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005543 IEA phospholipid binding
GO:0005545 IEA:ISS 1-phosphatidylinositol binding
GO:0005634 IDA nucleus
GO:0005794 IEA Golgi apparatus
GO:0005905 ISS coated pit
GO:0006461 TAS protein complex assembly
GO:0006898 ISS receptor-mediated endocytosis
GO:0008283 IMP cell proliferation
GO:0010629 IMP negative regulation of gene expression
GO:0016020 IDA membrane
GO:0016188 ISS synaptic vesicle maturation
GO:0016192 TAS vesicle-mediated transport
GO:0016197 IMP endosomal transport
GO:0030100 IMP regulation of endocytosis
GO:0030118 IEA clathrin coat
GO:0030122 IDA AP-2 adaptor complex
GO:0030132 IDA clathrin coat of coated pit
GO:0030276 IEA:ISS clathrin binding
GO:0031623 IMP receptor internalization
GO:0031982 ISS vesicle
GO:0032050 IDA clathrin heavy chain binding
GO:0032880 IDA regulation of protein localization
GO:0035459 IMP cargo loading into vesicle
GO:0035615 IMP clathrin adaptor activity
GO:0042734 ISS presynaptic membrane
GO:0043025 IDA neuronal cell body
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045211 ISS postsynaptic membrane
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0048261 IDA negative regulation of receptor-mediated endocytosis
GO:0048268 IEA:IMP clathrin coat assembly
GO:0048471 ISS perinuclear region of cytoplasm
GO:0055072 IMP iron ion homeostasis
GO:0072583 IMP clathrin-mediated endocytosis
GO:0097418 IMP neurofibrillary tangle
GO:0097459 IMP iron ion import into cell
GO:1901216 IMP positive regulation of neuron death
GO:1902004 IMP positive regulation of beta-amyloid formation
GO:1902959 IMP regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 ISS positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 ISS negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000049537 Picalm-201 protein_coding Mus_musculus 0 4855

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