C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000076984 MAP2K7 9606 + 19:7903843-7914478 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000397979 MAP2K7-002 7903891-7914478 protein_coding
  ENST00000397981 MAP2K7-001 7903843-7914478 protein_coding
  ENST00000397983 MAP2K7-003 7903885-7914459 protein_coding
  ENST00000465324 MAP2K7-006 7910214-7910735 retained_intron
  ENST00000468058 MAP2K7-004 7903880-7912565 retained_intron
  ENST00000475022 MAP2K7-005 7903907-7907066 retained_intron
  ENST00000494348 MAP2K7-008 7910076-7911105 retained_intron
  ENST00000498118 MAP2K7-007 7911099-7911356 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397979ENST00000397981ENST00000397983ENST00000468058ENST00000475022ENST00000494348
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397979 7.701±0.00 12.312±0.00 N/A 2.906±2.62 3.908±0.00 5.034±0.00 N/A 6.849±5.92 1.530±1.30 5.418±0.00 10.602±0.00 5.609±2.04 8.544±0.83 17.895±5.68
ENST00000397981 N/A N/A 0.721±0.00 0.396±0.00 2.847±0.00 0.543±0.00 0.176±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000397983 6.195±0.00 N/A 0.344±0.00 4.804±0.00 6.690±0.00 7.623±0.00 9.088±0.00 N/A 2.004±1.25 3.059±2.85 15.270±14.86 9.802±1.24 6.863±1.91 7.672±0.00
ENST00000468058 N/A N/A 0.858±0.00 1.804±0.00 3.570±0.00 2.464±0.00 0.863±0.00 1.397±0.00 1.110±0.00 2.267±0.00 1.239±0.00 9.801±8.62 21.634±0.00 34.402±0.00
ENST00000475022 N/A N/A 0.497±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000494348 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.336±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002FU CIL_0002FU_0001 CGP 19:7888505-7914478
CIL_0002FR CIL_0002FR_0001 CGP 19:7903843-7919097

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006950 IEA response to stress
GO:0006970 IDA response to osmotic stress
GO:0007165 TAS signal transduction
GO:0007254 TAS JNK cascade
GO:0007257 ISS activation of JUN kinase activity
GO:0008022 IEA protein C-terminus binding
GO:0008545 IEA JUN kinase kinase activity
GO:0009408 IDA response to heat
GO:0009411 IDA response to UV
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0019903 ISS protein phosphatase binding
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0034612 IDA response to tumor necrosis factor
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0051403 IDA stress-activated MAPK cascade
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008279 map2k7 mitogen-activated protein kinase kinase 7 protein_coding Danio_rerio
ENSMUSG00000002948 Map2k7 mitogen-activated protein kinase kinase 7 protein_coding Mus_musculus

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