C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002948 Map2k7 10090 + 8:4238740-4251423 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000003027 Map2k7-003 4238829-4247897 protein_coding
  ENSMUST00000062686 Map2k7-002 4238761-4247897 protein_coding
  ENSMUST00000110994 Map2k7-006 4240105-4247896 protein_coding
  ENSMUST00000110995 Map2k7-007 4240105-4247897 protein_coding
  ENSMUST00000110996 Map2k7-008 4243264-4245841 protein_coding
  ENSMUST00000110998 Map2k7-001 4238740-4247896 protein_coding
  ENSMUST00000110999 Map2k7-004 4238829-4247897 protein_coding
  ENSMUST00000129537 Map2k7-010 4244637-4246300 retained_intron
  ENSMUST00000129866 Map2k7-009 4244457-4246177 processed_transcript
  ENSMUST00000145165 Map2k7-005 4238865-4251423 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000062686ENSMUST00000110994ENSMUST00000110995ENSMUST00000110996ENSMUST00000110998ENSMUST00000129537ENSMUST00000145165
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000062686 13.511±3.21 13.079±1.10 10.050±0.17 N/A 11.480±4.02 5.687±1.60 14.268±1.44 4.714±1.53 3.578±1.04 12.320±1.77 25.093±0.87 14.445±2.49 3.294±1.19 N/A
ENSMUST00000110994 N/A N/A N/A 20.077±0.00 N/A N/A N/A N/A 4.051±0.12 N/A N/A 23.409±1.12 N/A 19.131±9.58
ENSMUST00000110995 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 97.215±0.92
ENSMUST00000110996 N/A N/A N/A 45.086±0.00 N/A N/A N/A N/A N/A N/A N/A 44.718±0.00 31.749±8.87 112.439±0.00
ENSMUST00000110998 7.069±1.71 13.898±1.55 7.090±1.42 24.061±2.00 8.180±2.37 10.496±2.47 3.132±0.26 9.239±1.91 9.357±1.06 10.778±2.03 N/A 14.064±3.32 8.112±0.92 11.605±1.18
ENSMUST00000129537 N/A N/A N/A N/A N/A 13.398±1.81 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000145165 N/A 10.815±2.34 N/A N/A 6.150±0.34 4.092±0.76 N/A 3.582±0.37 2.880±0.14 N/A N/A 9.487±1.36 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002FU CIL_0002FU_0002 CGP 8:4226827-4251423
CIL_0002FR CIL_0002FR_0002 CGP 8:4238740-4251423

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006915 IEA apoptotic process
GO:0006950 IDA response to stress
GO:0006970 IEA response to osmotic stress
GO:0007254 IEA JNK cascade
GO:0007257 IDA activation of JUN kinase activity
GO:0008022 IEA protein C-terminus binding
GO:0008545 IEA JUN kinase kinase activity
GO:0009408 IEA response to heat
GO:0009411 IEA response to UV
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0034612 IEA response to tumor necrosis factor
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0051403 IDA stress-activated MAPK cascade
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008279 map2k7 mitogen-activated protein kinase kinase 7 protein_coding Danio_rerio
ENSG00000076984 MAP2K7 mitogen-activated protein kinase kinase 7 protein_coding Homo_sapiens

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