C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenylate cyclase 2 (brain)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000078295 ADCY2 9606 + 5:7396208-7830081 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338316 ADCY2-001 7396208-7830081 protein_coding
  ENST00000382531 ADCY2-003 7782173-7816874 processed_transcript
  ENST00000484965 ADCY2-006 7414629-7522622 processed_transcript
  ENST00000489501 ADCY2-002 7793619-7827532 retained_intron
  ENST00000493243 ADCY2-004 7773068-7820689 nonsense_mediated_decay
  ENST00000498598 ADCY2-005 7414664-7658206 processed_transcript
  ENST00000513693 ADCY2-007 7685091-7692271 processed_transcript
  ENST00000515681 ADCY2-008 7611109-7695816 protein_coding
  ENST00000537121 ADCY2-201 7396271-7827531 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338316ENST00000382531ENST00000489501ENST00000493243ENST00000498598ENST00000513693ENST00000515681ENST00000537121
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338316 N/A N/A N/A 4.018±0.63 N/A N/A 0.052±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000382531 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.712±0.00 2.205±0.00 4.097±0.00
ENST00000489501 N/A 0.046±0.00 0.005±0.00 N/A N/A 0.066±0.00 0.009±0.01 0.028±0.00 0.228±0.00 0.055±0.01 N/A 0.055±0.02 N/A N/A
ENST00000493243 N/A N/A N/A N/A N/A N/A N/A 0.064±0.00 N/A N/A N/A N/A 1.931±0.00 N/A
ENST00000498598 N/A N/A N/A N/A N/A 1.541±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000513693 N/A N/A N/A N/A N/A N/A N/A 0.121±0.00 0.021±0.00 N/A N/A N/A N/A N/A
ENST00000515681 N/A N/A 0.147±0.00 N/A 1.395±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000537121 0.342±0.00 0.550±0.00 0.066±0.00 20.442±8.75 1.116±0.64 1.948±1.80 0.071±0.02 0.232±0.00 0.839±0.00 0.689±0.00 20.138±8.05 1.190±1.04 1.378±0.55 3.732±0.69

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004016 ISS:IEA adenylate cyclase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005622 ISS intracellular
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006112 TAS energy reserve metabolic process
GO:0006171 ISS cAMP biosynthetic process
GO:0006833 TAS water transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007188 ISS adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 TAS adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 TAS adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007268 TAS synaptic transmission
GO:0008179 ISS adenylate cyclase binding
GO:0008294 IEA calcium- and calmodulin-responsive adenylate cyclase activity
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009190 IEA cyclic nucleotide biosynthetic process
GO:0016020 ISS membrane
GO:0016021 IEA integral component of membrane
GO:0016849 IEA phosphorus-oxygen lyase activity
GO:0030425 ISS dendrite
GO:0031683 IEA G-protein beta/gamma-subunit complex binding
GO:0034199 TAS activation of protein kinase A activity
GO:0035556 IEA intracellular signal transduction
GO:0043234 IEA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045121 ISS membrane raft
GO:0046872 IEA metal ion binding
GO:0046982 ISS protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0055085 TAS transmembrane transport
GO:0071377 TAS cellular response to glucagon stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014588 adcy2b adenylate cyclase 2b (brain) protein_coding Danio_rerio
ENSDARG00000058392 adcy2a adenylate cyclase 2a protein_coding Danio_rerio
ENSMUSG00000021536 Adcy2 adenylate cyclase 2 protein_coding Mus_musculus

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