C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kelch-like ECH-associated protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000079999 KEAP1 9606 - 19:10486120-10503741 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000171111 KEAP1-001 10486120-10503741 protein_coding
  ENST00000393623 KEAP1-002 10486126-10502896 protein_coding
  ENST00000585845 KEAP1-010 10491999-10503558 nonsense_mediated_decay
  ENST00000588024 KEAP1-007 10491947-10499509 processed_transcript
  ENST00000590237 KEAP1-009 10486612-10489435 retained_intron
  ENST00000590593 KEAP1-008 10486718-10491880 nonsense_mediated_decay
  ENST00000591039 KEAP1-006 10499398-10502685 protein_coding
  ENST00000591419 KEAP1-005 10499395-10502687 protein_coding
  ENST00000592055 KEAP1-004 10492064-10503186 protein_coding
  ENST00000592478 KEAP1-003 10486125-10491720 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000171111ENST00000393623ENST00000585845ENST00000590237ENST00000590593ENST00000592478
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000171111 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.455±0.00 N/A 5.471±0.00 N/A N/A
ENST00000393623 30.654±0.00 13.845±0.00 N/A 17.096±0.00 19.742±0.00 8.431±6.39 12.108±10.56 13.484±0.00 4.498±0.00 3.287±0.00 100.255±0.00 17.541±14.37 9.983±0.62 15.460±7.98
ENST00000585845 N/A N/A N/A N/A 4.861±0.00 N/A N/A N/A 3.961±0.00 N/A 7.756±0.00 4.355±0.00 N/A N/A
ENST00000590237 N/A N/A 4.727±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 3.002±0.00 N/A N/A
ENST00000590593 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 25.578±0.00 21.750±0.00 10.738±0.00
ENST00000592478 N/A 8.116±0.00 N/A 10.692±0.00 N/A 11.269±0.00 N/A 12.258±0.00 5.258±4.43 N/A N/A 8.749±0.00 6.605±0.00 17.154±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004FB CIL_0004FB_0001 CGP 19:10416773-10503741
CIL_000777 CIL_000777_0002 CGP 19:10486120-10517931

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005815 IDA microtubule organizing center
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0008134 IPI transcription factor binding
GO:0010499 IDA proteasomal ubiquitin-independent protein catabolic process
GO:0016567 IEA protein ubiquitination
GO:0030496 IDA midbody
GO:0031463 IDA Cul3-RING ubiquitin ligase complex
GO:0032436 TAS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043433 TAS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045604 IEA regulation of epidermal cell differentiation
GO:0071353 IEA cellular response to interleukin-4

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074634 keap1b kelch-like ECH-associated protein 1b protein_coding Danio_rerio
ENSMUSG00000003308 Keap1 kelch-like ECH-associated protein 1 protein_coding Mus_musculus

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