C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD59 molecule, complement regulatory protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000085063 CD59 9606 - 11:33698261-33736445 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000351554 CD59-001 33708865-33736445 protein_coding
  ENST00000395850 CD59-002 33708700-33736439 protein_coding
  ENST00000415002 CD59-003 33708900-33722710 protein_coding
  ENST00000426650 CD59-007 33709826-33722952 protein_coding
  ENST00000437761 CD59-009 33709929-33722726 protein_coding
  ENST00000445143 CD59-008 33709798-33722727 protein_coding
  ENST00000525763 CD59-011 33698355-33722467 nonsense_mediated_decay
  ENST00000527577 CD59-005 33710005-33736425 protein_coding
  ENST00000527926 CD59-013 33698262-33722448 nonsense_mediated_decay
  ENST00000528700 CD59-006 33710081-33736422 protein_coding
  ENST00000528987 CD59-004 33708870-33719611 retained_intron
  ENST00000533181 CD59-014 33702692-33710283 nonsense_mediated_decay
  ENST00000533403 CD59-010 33708833-33736408 protein_coding
  ENST00000534312 CD59-012 33698261-33722456 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000351554ENST00000395850ENST00000426650
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000351554 109.908±0.00 96.008±0.00 9.638±0.00 36.185±18.83 47.321±30.25 44.406±29.90 48.286±23.96 67.448±52.70 24.682±3.63 98.550±62.86 34.784±3.58 30.108±13.28 101.924±13.27 60.284±9.77
ENST00000395850 120.475±0.00 106.005±0.00 10.952±0.00 31.349±17.73 55.868±18.24 54.669±45.91 82.002±0.00 59.173±44.72 23.235±0.93 87.769±66.46 28.784±6.13 48.744±36.08 112.852±12.14 58.750±0.00
ENST00000426650 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 174.698±18.36 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000929 CIL_000929_0001 VISTA 11:33642739-34246310

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001775 IBA cell activation
GO:0001848 IBA complement binding
GO:0001971 IEA negative regulation of activation of membrane attack complex
GO:0005515 IPI protein binding
GO:0005576 IBA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0009986 IDA cell surface
GO:0016020 TAS membrane
GO:0030449 TAS regulation of complement activation
GO:0031362 IDA anchored component of external side of plasma membrane
GO:0031982 IDA vesicle
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042383 IEA sarcolemma
GO:0043066 IEA negative regulation of apoptotic process
GO:0043218 IEA compact myelin
GO:0045087 TAS innate immune response
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000032679 Cd59a CD59a antigen protein_coding Mus_musculus
ENSMUSG00000068686 Cd59b CD59b antigen protein_coding Mus_musculus

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