C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000085511 MAP3K4 9606 + 6:160991727-161117385 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000348824 MAP3K4-007 160991814-161117382 protein_coding
  ENST00000366919 MAP3K4-002 160991727-161117385 protein_coding
  ENST00000366920 MAP3K4-006 160991814-161117382 protein_coding
  ENST00000392142 MAP3K4-001 160991784-161117385 protein_coding
  ENST00000446500 MAP3K4-003 161034358-161048803 processed_transcript
  ENST00000448119 MAP3K4-010 161022194-161034449 protein_coding
  ENST00000490904 MAP3K4-004 160991844-161117308 nonsense_mediated_decay
  ENST00000536852 MAP3K4-008 161101033-161117384 retained_intron
  ENST00000539610 MAP3K4-014 161108879-161109886 retained_intron
  ENST00000540205 MAP3K4-012 161080683-161086599 retained_intron
  ENST00000541901 MAP3K4-016 161097166-161108933 retained_intron
  ENST00000542851 MAP3K4-011 161073329-161086444 retained_intron
  ENST00000542952 MAP3K4-009 160991769-161073536 nonsense_mediated_decay
  ENST00000543421 MAP3K4-013 161096697-161101992 retained_intron
  ENST00000544041 MAP3K4-005 160991844-161117308 nonsense_mediated_decay
  ENST00000544733 MAP3K4-015 161098240-161108754 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000348824ENST00000366919ENST00000366920ENST00000392142ENST00000490904ENST00000536852ENST00000544041
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000348824 2.606±0.00 N/A 1.357±0.00 1.553±0.00 1.996±0.00 3.259±0.52 1.439±0.55 2.714±0.00 0.544±0.00 0.906±0.00 3.024±0.44 2.254±1.22 1.894±0.47 5.012±0.00
ENST00000366919 N/A N/A N/A N/A 1.428±0.00 N/A 0.811±0.30 1.304±0.00 1.271±1.04 0.982±0.00 N/A 2.320±1.75 1.834±1.38 N/A
ENST00000366920 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.606±0.32
ENST00000392142 N/A N/A N/A 1.281±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000490904 N/A 1.134±0.00 N/A N/A N/A N/A N/A 0.686±0.00 N/A N/A N/A N/A N/A N/A
ENST00000536852 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.594±0.00 N/A 2.420±0.00 N/A N/A
ENST00000544041 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.870±0.00 N/A 1.190±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007Y5 CIL_0007Y5_0001 VISTA 6:160860643-161462319

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000186 IDA activation of MAPKK activity
GO:0001890 IEA placenta development
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006468 IEA protein phosphorylation
GO:0010225 IMP response to UV-C
GO:0010468 IEA regulation of gene expression
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019100 IEA male germ-line sex determination
GO:0035556 ISS intracellular signal transduction
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0046872 IEA metal ion binding
GO:0060718 IEA chorionic trophoblast cell differentiation
GO:1900745 IDA positive regulation of p38MAPK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053303 map3k4 mitogen activated protein kinase kinase kinase 4 protein_coding Danio_rerio
ENSMUSG00000014426 Map3k4 mitogen-activated protein kinase kinase kinase 4 protein_coding Mus_musculus

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