C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2-alpha kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000086232 EIF2AK1 9606 - 7:6022244-6059230 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000199389 EIF2AK1-001 6022244-6059230 protein_coding
  ENST00000422786 EIF2AK1-011 6023176-6026552 protein_coding
  ENST00000431744 EIF2AK1-003 6046071-6059164 nonsense_mediated_decay
  ENST00000446699 EIF2AK1-004 6047204-6059164 protein_coding
  ENST00000461493 EIF2AK1-005 6049784-6059175 retained_intron
  ENST00000463213 EIF2AK1-006 6046723-6059056 retained_intron
  ENST00000470168 EIF2AK1-002 6041153-6046437 retained_intron
  ENST00000474029 EIF2AK1-007 6040976-6046980 processed_transcript
  ENST00000490523 EIF2AK1-010 6024356-6028839 retained_intron
  ENST00000495565 EIF2AK1-008 6040959-6046902 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000199389ENST00000490523
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000199389 16.351±0.00 3.958±0.00 6.324±0.00 18.353±8.88 13.439±3.97 10.628±0.84 3.168±0.39 8.003±3.38 3.237±0.07 3.503±0.32 1.876±0.00 19.238±7.21 26.231±11.22 6.648±1.23
ENST00000490523 N/A N/A N/A N/A N/A 7.926±0.00 N/A N/A N/A N/A N/A 34.656±0.00 42.608±0.00 12.685±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002VB CIL_0002VB_0001 CGP 7:6022244-6059230

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004694 IDA eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0006417 IEA regulation of translation
GO:0006468 IEA protein phosphorylation
GO:0006950 IEP response to stress
GO:0008285 IEA negative regulation of cell proliferation
GO:0009605 IEP response to external stimulus
GO:0010999 IEA regulation of eIF2 alpha phosphorylation by heme
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0020037 ISS heme binding
GO:0042803 ISS protein homodimerization activity
GO:0045993 NAS negative regulation of translational initiation by iron
GO:0046501 IEA protoporphyrinogen IX metabolic process
GO:0046777 ISS protein autophosphorylation
GO:0046984 IEA regulation of hemoglobin biosynthetic process
GO:0046986 ISS negative regulation of hemoglobin biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000093182 eif2ak1 eukaryotic translation initiation factor 2-alpha kinase 1 protein_coding Danio_rerio
ENSMUSG00000029613 Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 protein_coding Mus_musculus

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