C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: eukaryotic translation initiation factor 2-alpha kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000199389 EIF2AK1-001 ENSG00000086232 9606 - 7:6022244-6059230 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000199389
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000199389 16.351±0.00 3.958±0.00 6.324±0.00 18.353±8.88 13.439±3.97 10.628±0.84 3.168±0.39 8.003±3.38 3.237±0.07 3.503±0.32 1.876±0.00 19.238±7.21 26.231±11.22 6.648±1.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002VB CIL_0002VB_0001 CGP 7:6022244-6059230

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004694 IDA eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0006417 IEA regulation of translation
GO:0006468 IEA protein phosphorylation
GO:0006950 IEP response to stress
GO:0008285 IEA negative regulation of cell proliferation
GO:0009605 IEP response to external stimulus
GO:0010999 IEA regulation of eIF2 alpha phosphorylation by heme
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0020037 ISS heme binding
GO:0042803 ISS protein homodimerization activity
GO:0045993 NAS negative regulation of translational initiation by iron
GO:0046501 IEA protoporphyrinogen IX metabolic process
GO:0046777 ISS protein autophosphorylation
GO:0046984 IEA regulation of hemoglobin biosynthetic process
GO:0046986 ISS negative regulation of hemoglobin biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000100487 Eif2ak1-001 protein_coding Mus_musculus 0 1707
ENSMUST00000100483 Aimp2-002 protein_coding Mus_musculus 0 355
ENSMUST00000031613 Aimp2-001 protein_coding Mus_musculus 0 355
ENSMUST00000110718 Ankrd61-003 protein_coding Mus_musculus 1e-27 130

Loading