C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2 alpha kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029613 Eif2ak1 10090 + 5:143817788-143904256 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000100487 Eif2ak1-001 143817788-143904256 protein_coding
  ENSMUST00000140013 Eif2ak1-002 143817831-143880479 retained_intron
  ENSMUST00000154767 Eif2ak1-003 143817947-143874265 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000100487ENSMUST00000140013
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000100487 9.220±1.69 17.662±4.58 4.882±2.19 15.545±4.40 10.814±1.61 16.838±1.83 5.586±0.64 15.546±1.39 23.512±17.48 9.627±2.44 8.157±3.48 14.526±4.04 12.069±8.42 9.723±1.01
ENSMUST00000140013 N/A 28.106±2.76 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BI CIL_0005BI_0002 CGP 5:143710325-143904256
CIL_0002VB CIL_0002VB_0002 CGP 5:143817788-143904256

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IMP protein kinase activity
GO:0004694 ISS eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006417 IMP regulation of translation
GO:0006950 ISS response to stress
GO:0008285 IDA negative regulation of cell proliferation
GO:0009605 ISS response to external stimulus
GO:0010999 IGI regulation of eIF2 alpha phosphorylation by heme
GO:0017148 IEA negative regulation of translation
GO:0020037 IDA heme binding
GO:0042803 IPI protein homodimerization activity
GO:0046501 IGI protoporphyrinogen IX metabolic process
GO:0046777 IEP protein autophosphorylation
GO:0046984 IGI regulation of hemoglobin biosynthetic process
GO:0046986 IDA negative regulation of hemoglobin biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000093182 eif2ak1 eukaryotic translation initiation factor 2-alpha kinase 1 protein_coding Danio_rerio
ENSG00000086232 EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 protein_coding Homo_sapiens

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