C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: metallothionein 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000561640 MT3-004 ENSG00000087250 9606 + 16:56589074-56591075 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainLiverENST00000561640
Transcript ID Brain Liver
ENST00000561640 51.914±0.00 0.163±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048X CIL_00048X_0001 CGP 16:56565049-56591088

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000060 IDA protein import into nucleus, translocation
GO:0001666 IDA response to hypoxia
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0005507 IDA copper ion binding
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005737 IDA cytoplasm
GO:0006112 ISS energy reserve metabolic process
GO:0006707 ISS cholesterol catabolic process
GO:0006829 ISS zinc ion transport
GO:0006875 NAS cellular metal ion homeostasis
GO:0006882 ISS cellular zinc ion homeostasis
GO:0008021 ISS synaptic vesicle
GO:0008144 IDA drug binding
GO:0008270 IDA zinc ion binding
GO:0008283 TAS cell proliferation
GO:0010507 ISS negative regulation of autophagy
GO:0010628 ISS positive regulation of gene expression
GO:0010940 IDA positive regulation of necrotic cell death
GO:0010942 ISS positive regulation of cell death
GO:0014002 ISS astrocyte development
GO:0016209 NAS antioxidant activity
GO:0016234 IDA inclusion body
GO:0016570 IMP histone modification
GO:0019430 IDA removal of superoxide radicals
GO:0030295 IDA protein kinase activator activity
GO:0030308 IDA negative regulation of cell growth
GO:0030517 IDA negative regulation of axon extension
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095 ISS regulation of response to food
GO:0032148 IDA activation of protein kinase B activity
GO:0033210 ISS leptin-mediated signaling pathway
GO:0034599 IEP cellular response to oxidative stress
GO:0035690 IDA cellular response to drug
GO:0036091 IDA positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043027 IDA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043085 ISS positive regulation of catalytic activity
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 IDA protein kinase B signaling
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0044242 ISS cellular lipid catabolic process
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0046870 IDA cadmium ion binding
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050821 IDA protein stabilization
GO:0051354 IDA negative regulation of oxidoreductase activity
GO:0055069 IDA zinc ion homeostasis
GO:0055073 IDA cadmium ion homeostasis
GO:0060049 ISS regulation of protein glycosylation
GO:0060547 ISS negative regulation of necrotic cell death
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071276 IDA cellular response to cadmium ion
GO:0071456 IEP cellular response to hypoxia
GO:0071732 IDA cellular response to nitric oxide
GO:0097214 ISS positive regulation of lysosomal membrane permeability
GO:2000117 IDA negative regulation of cysteine-type endopeptidase activity
GO:2000376 ISS positive regulation of oxygen metabolic process
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034211 Mt3-201 protein_coding Mus_musculus 0 257
ENSMUST00000034215 Mt1-201 protein_coding Mus_musculus 2e-17 94

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