C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000094631 HDAC6 9606 + X:48801377-48824982 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000334136 HDAC6-001 48801995-48824976 protein_coding
  ENST00000376610 HDAC6-023 48801949-48806706 protein_coding
  ENST00000376619 HDAC6-017 48802034-48824976 protein_coding
  ENST00000376643 HDAC6-007 48801700-48806706 protein_coding
  ENST00000423941 HDAC6-020 48801377-48805661 protein_coding
  ENST00000426196 HDAC6-015 48802192-48808328 protein_coding
  ENST00000430858 HDAC6-016 48823518-48824976 protein_coding
  ENST00000438518 HDAC6-021 48801396-48802930 protein_coding
  ENST00000440653 HDAC6-031 48802550-48806445 protein_coding
  ENST00000441703 HDAC6-028 48802187-48806413 protein_coding
  ENST00000443563 HDAC6-030 48802515-48806431 protein_coding
  ENST00000461608 HDAC6-010 48806419-48806959 retained_intron
  ENST00000462730 HDAC6-003 48802016-48806946 retained_intron
  ENST00000465269 HDAC6-004 48802064-48805855 retained_intron
  ENST00000465457 HDAC6-035 48815799-48817336 retained_intron
  ENST00000468949 HDAC6-032 48802780-48806648 retained_intron
  ENST00000469223 HDAC6-022 48801793-48808137 processed_transcript
  ENST00000470942 HDAC6-037 48816570-48820203 retained_intron
  ENST00000476625 HDAC6-005 48802082-48806233 retained_intron
  ENST00000477528 HDAC6-002 48802055-48824982 retained_intron
  ENST00000477561 HDAC6-025 48802110-48808270 processed_transcript
  ENST00000478095 HDAC6-026 48814540-48815428 retained_intron
  ENST00000480525 HDAC6-012 48818071-48823109 processed_transcript
  ENST00000481929 HDAC6-027 48802186-48805745 retained_intron
  ENST00000483506 HDAC6-038 48816960-48818085 retained_intron
  ENST00000483656 HDAC6-024 48801991-48808046 processed_transcript
  ENST00000485102 HDAC6-033 48814765-48816176 retained_intron
  ENST00000486227 HDAC6-018 48813353-48824976 retained_intron
  ENST00000486665 HDAC6-036 48816473-48820180 processed_transcript
  ENST00000488543 HDAC6-019 48819447-48824976 retained_intron
  ENST00000488905 HDAC6-034 48815269-48815844 retained_intron
  ENST00000489053 HDAC6-039 48817638-48818286 retained_intron
  ENST00000489352 HDAC6-029 48802207-48805846 retained_intron
  ENST00000493923 HDAC6-009 48802908-48803439 retained_intron
  ENST00000495515 HDAC6-013 48816190-48816953 retained_intron
  ENST00000498808 HDAC6-040 48817456-48823079 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000334136ENST00000376619ENST00000430858ENST00000441703ENST00000443563ENST00000477528ENST00000481929ENST00000485102ENST00000486227ENST00000488543
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000334136 7.706±0.00 5.240±0.00 N/A 5.572±4.53 4.152±3.08 1.735±0.00 N/A 6.464±0.00 N/A N/A 7.244±0.00 9.608±7.71 3.368±0.00 4.313±0.00
ENST00000376619 N/A N/A N/A N/A N/A N/A 3.361±0.00 N/A 4.233±0.00 5.778±0.00 N/A 11.433±2.28 7.403±1.52 6.898±1.96
ENST00000430858 N/A N/A N/A N/A N/A N/A N/A 18.921±0.00 13.480±0.00 10.972±0.00 8.700±0.00 N/A N/A N/A
ENST00000441703 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.089±0.00 N/A
ENST00000443563 N/A N/A 34.973±0.00 11.683±0.00 9.224±0.00 9.533±0.00 4.679±0.00 53.310±0.00 12.296±0.00 19.527±0.00 3.656±0.00 21.640±0.00 N/A N/A
ENST00000477528 N/A N/A 1.915±0.00 0.736±0.00 0.548±0.00 1.432±0.32 0.630±0.00 N/A 1.658±0.00 1.562±0.00 N/A 1.280±0.00 N/A 6.635±0.00
ENST00000481929 N/A N/A N/A N/A 3.636±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000485102 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 38.173±0.00 18.978±0.00 50.097±0.00
ENST00000486227 N/A N/A 1.812±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000488543 N/A 5.439±0.00 3.260±0.00 1.352±0.00 N/A 1.837±0.00 N/A 4.551±0.00 N/A N/A 1.492±0.00 11.640±0.00 N/A 15.233±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 IDA histone deacetylase complex
GO:0000209 IEA protein polyubiquitination
GO:0001047 IDA core promoter binding
GO:0003779 IEA actin binding
GO:0004407 IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0005874 IDA microtubule
GO:0005875 IDA microtubule associated complex
GO:0005881 IEA cytoplasmic microtubule
GO:0005901 IDA caveola
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IMP protein deacetylation
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006515 IMP misfolded or incompletely synthesized protein catabolic process
GO:0006886 IMP intracellular protein transport
GO:0007026 IEA negative regulation of microtubule depolymerization
GO:0008013 IPI beta-catenin binding
GO:0008017 ISS microtubule binding
GO:0008270 IEA zinc ion binding
GO:0009636 IMP response to toxic substance
GO:0009967 IMP positive regulation of signal transduction
GO:0010033 IMP response to organic substance
GO:0010469 IMP regulation of receptor activity
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0010727 IC negative regulation of hydrogen peroxide metabolic process
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0016234 IDA inclusion body
GO:0016235 IDA aggresome
GO:0016236 IMP macroautophagy
GO:0016575 IDA histone deacetylation
GO:0019899 ISS enzyme binding
GO:0030286 IDA dynein complex
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031252 IDA cell leading edge
GO:0031593 IDA polyubiquitin binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 IMP lysosome localization
GO:0034983 IMP peptidyl-lysine deacetylation
GO:0035967 IMP cellular response to topologically incorrect protein
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042826 IPI histone deacetylase binding
GO:0042903 ISS tubulin deacetylase activity
GO:0043014 IDA alpha-tubulin binding
GO:0043130 IEA ubiquitin binding
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 ISS perikaryon
GO:0043234 IEA protein complex
GO:0043241 IEA protein complex disassembly
GO:0043242 IMP negative regulation of protein complex disassembly
GO:0045598 IEA regulation of fat cell differentiation
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156 IDA tau protein binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048487 IEA beta-tubulin binding
GO:0051354 IC negative regulation of oxidoreductase activity
GO:0051788 IMP response to misfolded protein
GO:0051879 IDA Hsp90 protein binding
GO:0060632 IC regulation of microtubule-based movement
GO:0060765 TAS regulation of androgen receptor signaling pathway
GO:0070201 IEA regulation of establishment of protein localization
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0070840 IDA dynein complex binding
GO:0070842 IMP aggresome assembly
GO:0070845 IMP polyubiquitinated misfolded protein transport
GO:0070846 IMP Hsp90 deacetylation
GO:0070848 IMP response to growth factor
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0071218 IEA cellular response to misfolded protein
GO:0090035 IMP positive regulation of chaperone-mediated protein complex assembly
GO:0090042 ISS tubulin deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:1901300 IDA positive regulation of hydrogen peroxide-mediated programmed cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008384 hdac6 histone deacetylase 6 protein_coding Danio_rerio
ENSMUSG00000031161 Hdac6 histone deacetylase 6 protein_coding Mus_musculus

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