C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031161 Hdac6 10090 - X:7930120-7947889 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033501 Hdac6-201 7930122-7947889 protein_coding
  ENSMUST00000115642 Hdac6-001 7930120-7947889 protein_coding
  ENSMUST00000133349 Hdac6-005 7943423-7947553 protein_coding
  ENSMUST00000137499 Hdac6-002 7930124-7947838 retained_intron
  ENSMUST00000145675 Hdac6-003 7931359-7947889 protein_coding
  ENSMUST00000151916 Hdac6-008 7937322-7938672 retained_intron
  ENSMUST00000153788 Hdac6-009 7931555-7934485 retained_intron
  ENSMUST00000154200 Hdac6-006 7943399-7947159 retained_intron
  ENSMUST00000154244 Hdac6-004 7946994-7947767 protein_coding
  ENSMUST00000156127 Hdac6-007 7937429-7939964 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033501ENSMUST00000115642ENSMUST00000137499ENSMUST00000151916
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033501 2.792±1.44 5.107±2.63 2.427±1.11 8.618±3.77 2.506±0.00 2.398±0.97 1.306±0.26 7.992±2.07 2.353±0.54 1.566±0.60 1.212±0.40 3.923±0.94 9.864±7.04 6.328±1.28
ENSMUST00000115642 7.561±2.19 5.879±2.24 3.306±0.98 13.427±8.83 7.436±2.48 5.448±1.17 3.076±0.27 15.607±3.53 4.886±1.57 3.914±0.61 0.917±0.48 17.018±8.29 10.822±6.01 10.954±4.92
ENSMUST00000137499 1.870±0.23 N/A N/A 2.021±0.00 1.618±0.07 1.025±0.06 0.462±0.00 N/A 0.792±0.00 1.028±0.16 N/A 2.317±0.52 3.285±1.31 2.741±0.13
ENSMUST00000151916 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.403±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00029K CIL_00029K_0002 CGP X:7930120-7978071

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 IEA histone deacetylase complex
GO:0000209 IDA protein polyubiquitination
GO:0001047 IEA core promoter binding
GO:0003779 IEA actin binding
GO:0004407 IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005874 IEA microtubule
GO:0005875 IEA microtubule associated complex
GO:0005881 IDA cytoplasmic microtubule
GO:0005901 IEA caveola
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006476 IDA protein deacetylation
GO:0006511 IGI ubiquitin-dependent protein catabolic process
GO:0006515 IEA misfolded or incompletely synthesized protein catabolic process
GO:0006886 IEA intracellular protein transport
GO:0007026 IDA negative regulation of microtubule depolymerization
GO:0008013 IEA beta-catenin binding
GO:0008017 IDA microtubule binding
GO:0008270 IEA zinc ion binding
GO:0009636 IEA response to toxic substance
GO:0009967 IEA positive regulation of signal transduction
GO:0010033 IEA response to organic substance
GO:0010469 IEA regulation of receptor activity
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0010870 IEA positive regulation of receptor biosynthetic process
GO:0016234 IEA inclusion body
GO:0016235 IEA aggresome
GO:0016236 IEA macroautophagy
GO:0016575 IDA histone deacetylation
GO:0030286 IEA dynein complex
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0031252 IEA cell leading edge
GO:0031593 IEA polyubiquitin binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 IEA lysosome localization
GO:0034983 IEA peptidyl-lysine deacetylation
GO:0035967 IEA cellular response to topologically incorrect protein
GO:0040029 IEA regulation of gene expression, epigenetic
GO:0042826 IEA histone deacetylase binding
GO:0042903 IDA tubulin deacetylase activity
GO:0043014 IEA alpha-tubulin binding
GO:0043130 IDA ubiquitin binding
GO:0043162 IMP ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 IDA perikaryon
GO:0043234 IPI protein complex
GO:0043241 IGI protein complex disassembly
GO:0043242 IEA negative regulation of protein complex disassembly
GO:0045598 IMP regulation of fat cell differentiation
GO:0045861 IEA negative regulation of proteolysis
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156 IEA tau protein binding
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048487 IDA beta-tubulin binding
GO:0051788 IEA response to misfolded protein
GO:0051879 IEA Hsp90 protein binding
GO:0070201 IMP regulation of establishment of protein localization
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0070840 IEA dynein complex binding
GO:0070842 IGI aggresome assembly
GO:0070845 IEA polyubiquitinated misfolded protein transport
GO:0070846 IMP Hsp90 deacetylation
GO:0070848 IEA response to growth factor
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0071218 IMP cellular response to misfolded protein
GO:0090035 IEA positive regulation of chaperone-mediated protein complex assembly
GO:0090042 IMP tubulin deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:1901300 IEA positive regulation of hydrogen peroxide-mediated programmed cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008384 hdac6 histone deacetylase 6 protein_coding Danio_rerio
ENSG00000094631 HDAC6 histone deacetylase 6 protein_coding Homo_sapiens

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