C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sorbin and SH3 domain containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095637 SORBS1 9606 - 10:95311771-95561414 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000277982 SORBS1-005 95315025-95441162 protein_coding
  ENST00000306402 SORBS1-001 95311773-95561414 protein_coding
  ENST00000354106 SORBS1-008 95315059-95441135 protein_coding
  ENST00000361941 SORBS1-004 95315025-95441162 protein_coding
  ENST00000371227 SORBS1-015 95311771-95561378 protein_coding
  ENST00000371228 SORBS1-019 95341674-95356046 protein_coding
  ENST00000371239 SORBS1-009 95315059-95441135 protein_coding
  ENST00000371241 SORBS1-007 95315059-95441135 protein_coding
  ENST00000371245 SORBS1-006 95315025-95441162 protein_coding
  ENST00000371246 SORBS1-201 95311774-95561378 protein_coding
  ENST00000371247 SORBS1-202 95311774-95561378 protein_coding
  ENST00000371249 SORBS1-002 95311773-95561378 protein_coding
  ENST00000465489 SORBS1-012 95384051-95413764 processed_transcript
  ENST00000472854 SORBS1-013 95381413-95384285 processed_transcript
  ENST00000474353 SORBS1-014 95341584-95561373 processed_transcript
  ENST00000482068 SORBS1-010 95490737-95493185 processed_transcript
  ENST00000486141 SORBS1-016 95399017-95415695 protein_coding
  ENST00000492542 SORBS1-011 95414744-95482671 protein_coding
  ENST00000607232 SORBS1-017 95314737-95561355 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306402ENST00000361941ENST00000371227ENST00000371239ENST00000371241ENST00000371247ENST00000371249
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306402 21.555±0.00 14.944±0.00 0.670±0.00 7.072±2.91 81.851±0.00 11.821±0.00 N/A 4.579±0.00 N/A 4.072±0.00 N/A 2.973±1.42 5.167±3.42 10.553±6.24
ENST00000361941 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.920±0.00 N/A N/A N/A
ENST00000371227 N/A N/A N/A N/A N/A N/A 27.920±12.86 N/A N/A N/A 13.196±10.03 N/A N/A N/A
ENST00000371239 N/A N/A N/A 8.384±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000371241 N/A N/A 1.493±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000371247 N/A N/A N/A 3.062±0.00 N/A N/A 7.534±0.00 N/A N/A N/A 37.353±0.00 N/A N/A N/A
ENST00000371249 25.456±0.00 11.280±0.00 N/A N/A 26.193±17.30 30.818±0.00 N/A 2.603±0.41 26.713±0.00 4.555±0.01 N/A 1.643±0.57 1.470±0.38 17.515±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00095J CIL_00095J_0001 VISTA 10:95113366-95716533
CIL_0007T2 CIL_0007T2_0001 VISTA 10:95207959-95809585
CIL_00067J CIL_00067J_0001 CGP 10:95237572-95561414
CIL_00067I CIL_00067I_0001 CGP 10:95311771-95656706

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001725 ISS stress fiber
GO:0003779 TAS actin binding
GO:0005070 IC SH3/SH2 adaptor activity
GO:0005158 IDA insulin receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005829 ISS cytosol
GO:0005899 IDA insulin receptor complex
GO:0005913 ISS cell-cell adherens junction
GO:0005915 TAS zonula adherens
GO:0005924 ISS cell-substrate adherens junction
GO:0006936 TAS muscle contraction
GO:0007160 TAS cell-matrix adhesion
GO:0008092 TAS cytoskeletal protein binding
GO:0008286 ISS insulin receptor signaling pathway
GO:0009967 IC positive regulation of signal transduction
GO:0015758 ISS glucose transport
GO:0019901 IEA protein kinase binding
GO:0032869 ISS cellular response to insulin stimulus
GO:0043149 ISS stress fiber assembly
GO:0045121 ISS membrane raft
GO:0045725 ISS positive regulation of glycogen biosynthetic process
GO:0046326 ISS positive regulation of glucose import
GO:0046889 ISS positive regulation of lipid biosynthetic process
GO:0048041 ISS focal adhesion assembly
GO:0090004 ISS positive regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079230 sorbs1 sorbin and SH3 domain containing 1 protein_coding Danio_rerio
ENSMUSG00000025006 Sorbs1 sorbin and SH3 domain containing 1 protein_coding Mus_musculus

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