C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: triggering receptor expressed on myeloid cells 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095970 TREM2 9606 - 6:41158506-41163186 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338469 TREM2-002 41158507-41163186 protein_coding
  ENST00000373113 TREM2-001 41158507-41163176 protein_coding
  ENST00000373122 TREM2-003 41158506-41163103 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338469ENST00000373113ENST00000373122
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338469 0.512±0.00 N/A N/A N/A N/A N/A 1.123±0.00 0.163±0.09 1.050±0.00 0.047±0.00 0.064±0.00 N/A N/A
ENST00000373113 0.466±0.00 0.785±0.00 1.317±0.35 3.976±3.29 N/A 0.328±0.00 2.188±0.00 N/A 2.503±0.85 N/A 4.068±1.84 7.348±2.79 0.668±0.00
ENST00000373122 N/A N/A 2.502±0.00 N/A 1.018±0.00 0.311±0.10 N/A N/A N/A N/A 1.295±0.00 N/A 0.199±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008F3 CIL_0008F3_0001 VISTA 6:41112821-41713777

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001530 IEA lipopolysaccharide binding
GO:0002588 IDA positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0004872 TAS receptor activity
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005886 TAS plasma membrane
GO:0006959 TAS humoral immune response
GO:0007411 TAS axon guidance
GO:0016021 IDA integral component of membrane
GO:0032497 IEA detection of lipopolysaccharide
GO:0032499 IEA detection of peptidoglycan
GO:0042834 IEA peptidoglycan binding
GO:0045087 TAS innate immune response
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 IDA positive regulation of calcium-mediated signaling
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070392 IEA detection of lipoteichoic acid
GO:0070891 IEA lipoteichoic acid binding
GO:0071223 IEA cellular response to lipoteichoic acid
GO:0071224 IEA cellular response to peptidoglycan
GO:0097028 IDA dendritic cell differentiation
GO:0097110 IPI scaffold protein binding
GO:1903078 IDA positive regulation of protein localization to plasma membrane
GO:1903082 IDA positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350 IDA positive regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000023992 Trem2 triggering receptor expressed on myeloid cells 2 protein_coding Mus_musculus

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