C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: triggering receptor expressed on myeloid cells 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000023992 Trem2 10090 + 17:48346401-48354147 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024791 Trem2-001 48346401-48352273 protein_coding
  ENSMUST00000113237 Trem2-002 48346488-48352273 protein_coding
  ENSMUST00000132340 Trem2-003 48346440-48354147 retained_intron
  ENSMUST00000148545 Trem2-004 48346489-48350558 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024791ENSMUST00000113237ENSMUST00000132340ENSMUST00000148545
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024791 23.201±14.45 3.410±0.84 2.940±0.56 1.210±0.25 2.803±0.79 1.658±0.44 1.032±0.20 0.210±0.08 1.563±1.50 2.914±0.74 0.138±0.01 8.070±3.04 2.165±1.26 0.669±0.34
ENSMUST00000113237 3.116±0.33 0.953±0.26 0.625±0.05 1.674±1.12 1.037±0.34 0.735±0.31 0.373±0.00 0.271±0.12 0.415±0.24 0.889±0.18 0.228±0.11 2.548±1.14 0.742±0.59 N/A
ENSMUST00000132340 1.321±0.54 0.304±0.11 N/A 0.179±0.00 0.184±0.07 0.108±0.00 0.065±0.00 0.012±0.00 0.048±0.04 0.203±0.00 0.018±0.01 0.714±0.27 0.079±0.05 0.057±0.02
ENSMUST00000148545 N/A 2.679±0.90 N/A 3.073±0.00 N/A 0.985±0.11 N/A 0.192±0.00 0.066±0.01 N/A N/A 7.378±2.06 1.629±0.71 0.437±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008F3 CIL_0008F3_0002 VISTA 17:47757242-48358147

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001530 IDA lipopolysaccharide binding
GO:0002588 IEA positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0004888 ISS transmembrane signaling receptor activity
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005886 IEA plasma membrane
GO:0016021 IEA integral component of membrane
GO:0031663 IC lipopolysaccharide-mediated signaling pathway
GO:0032497 IDA detection of lipopolysaccharide
GO:0032499 IDA detection of peptidoglycan
GO:0042834 IDA peptidoglycan binding
GO:0045087 IC innate immune response
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070392 IDA detection of lipoteichoic acid
GO:0070891 IDA lipoteichoic acid binding
GO:0071223 IDA cellular response to lipoteichoic acid
GO:0071224 IDA cellular response to peptidoglycan
GO:0097028 IEA dendritic cell differentiation
GO:0097110 IEA scaffold protein binding
GO:1903078 IEA positive regulation of protein localization to plasma membrane
GO:1903082 IEA positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350 IEA positive regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000095970 TREM2 triggering receptor expressed on myeloid cells 2 protein_coding Homo_sapiens

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