Institute of Cardiovascular Regeneration Webtool Repository

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Code Context

                ),
                E_USER_WARNING
            );

$key = 'cake_dev_eng'
$value = array(
	'LC_MESSAGES' => array()
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false

Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]

Code Context

                ),
                E_USER_WARNING
            );

$key = 'default_citloci_list'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false

Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_list' to File cache [CORE/Cake/Cache/Cache.php, line 323]

Code Context

                ),
                E_USER_WARNING
            );

$key = 'default_citloci_list'
$value = array(
	(int) 0 => 'conserved_region_elements',
	(int) 1 => 'conserved_regions',
	(int) 2 => 'diffexp',
	(int) 3 => 'experiment',
	(int) 4 => 'expressed_transcripts',
	(int) 5 => 'external_accessions',
	(int) 6 => 'genes',
	(int) 7 => 'go_annotations',
	(int) 8 => 'homologues',
	(int) 9 => 'maptranscripttoregion',
	(int) 10 => 'organism',
	(int) 11 => 'sample',
	(int) 12 => 'study',
	(int) 13 => 'synonyms',
	(int) 14 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false

Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Warning (512): _cake_model_ cache was unable to write 'default_citloci_genes' to File cache [CORE/Cake/Cache/Cache.php, line 323]

Code Context

                ),
                E_USER_WARNING
            );

$key = 'default_citloci_genes'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false

Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

Warning (512): _cake_model_ cache was unable to write 'default_citloci_genes' to File cache [CORE/Cake/Cache/Cache.php, line 323]

Code Context

                ),
                E_USER_WARNING
            );

$key = 'default_citloci_genes'
$value = array(
	'id' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 32,
		'key' => 'primary',
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'gene_version' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'tax_id' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'assembly' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'chromosome' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'strand' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'start' => array(
		'type' => 'integer',
		'null' => false,
		'default' => null,
		'length' => (int) 11,
		'unsigned' => false
	),
	'end' => array(
		'type' => 'integer',
		'null' => false,
		'default' => null,
		'length' => (int) 11,
		'unsigned' => false
	),
	'gene_name' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'gene_source' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 64,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'gene_biotype' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 128,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'annotation_version' => array(
		'type' => 'string',
		'null' => false,
		'default' => null,
		'length' => (int) 8,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	),
	'gene_description' => array(
		'type' => 'string',
		'null' => true,
		'default' => null,
		'length' => (int) 128,
		'collate' => 'latin1_swedish_ci',
		'charset' => 'latin1'
	)
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false

Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

Gene Info
Description:	Janus kinase 2
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000096968	JAK2	9606	+	9:4985033-5128183	protein_coding
	Transcript Accession	Transcript Name	Position	Transcript Biotype
	ENST00000381652	JAK2-001	4985245-5128183	protein_coding
	ENST00000476574	JAK2-002	4985033-5022065	processed_transcript
	ENST00000487310	JAK2-004	5125965-5126974	processed_transcript

Gene Info

Description:

Janus kinase 2

Gene Accession

Gene Name

Tax ID

Strand

Position

Gene Biotype

ENSG00000096968

JAK2

9606

9:4985033-5128183

protein_coding

Transcript Accession

Transcript Name

Position

Transcript Biotype

ENST00000381652

JAK2-001

4985245-5128183

protein_coding

ENST00000476574

JAK2-002

4985033-5022065

processed_transcript

ENST00000487310

JAK2-004

5125965-5126974

processed_transcript

Transcript ID	Adipose	Adrenal	Bladder	Brain	Breast	Colon	Heart	Kidney	Liver	Lung	Muscle	Ovary	Placenta	Testis
ENST00000381652	4.178±0.00	3.797±0.00	0.493±0.00	2.476±0.94	3.696±1.17	1.963±0.00	6.641±0.00	2.685±0.00	2.282±1.81	7.536±3.60	1.453±0.06	1.695±1.00	1.256±0.52	5.147±0.57
ENST00000487310	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	1.019±0.00	N/A	N/A

Conserved Regions
Region ID	Sub-Region	Region Type	Position
CIL_0000NF	CIL_0000NF_0001	CGP	9:4792834-5128183
CIL_0000NG	CIL_0000NG_0001	CGP	9:4985033-5185668

Conserved Regions

Region ID

Sub-Region

Region Type

Position

CIL_0000NF

CIL_0000NF_0001

CGP

9:4792834-5128183

CIL_0000NG

CIL_0000NG_0001

CGP

9:4985033-5185668

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0000186	IEA	activation of MAPKK activity
GO:0004672	NAS:IEA	protein kinase activity
GO:0004713	ISS:IEA	protein tyrosine kinase activity
GO:0004715	IEA	non-membrane spanning protein tyrosine kinase activity
GO:0005102	IPI	receptor binding
GO:0005131	ISS	growth hormone receptor binding
GO:0005143	ISS	interleukin-12 receptor binding
GO:0005515	IPI	protein binding
GO:0005524	IEA	ATP binding
GO:0005634	IDA	nucleus
GO:0005737	IDA	cytoplasm
GO:0005829	TAS	cytosol
GO:0005856	IEA	cytoskeleton
GO:0005901	ISS	caveola
GO:0006468	TAS:IEA	protein phosphorylation
GO:0006915	ISS	apoptotic process
GO:0006919	ISS	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928	TAS	cellular component movement
GO:0006979	IEA	response to oxidative stress
GO:0007165	ISS	signal transduction
GO:0007167	ISS	enzyme linked receptor protein signaling pathway
GO:0007186	IEA	G-protein coupled receptor signaling pathway
GO:0007204	IEA	positive regulation of cytosolic calcium ion concentration
GO:0007259	TAS	JAK-STAT cascade
GO:0007260	ISS	tyrosine phosphorylation of STAT protein
GO:0007262	ISS	STAT protein import into nucleus
GO:0007498	TAS	mesoderm development
GO:0007596	TAS	blood coagulation
GO:0008022	IEA	protein C-terminus binding
GO:0008284	IEA	positive regulation of cell proliferation
GO:0008285	ISS	negative regulation of cell proliferation
GO:0008631	IEA	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755	IEA	hormone-mediated signaling pathway
GO:0010811	IDA	positive regulation of cell-substrate adhesion
GO:0014068	ISS	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020	IEA	membrane
GO:0016363	IEA	nuclear matrix
GO:0016772	IEA	transferase activity, transferring phosphorus-containing groups
GO:0018108	ISS	peptidyl-tyrosine phosphorylation
GO:0019221	ISS	cytokine-mediated signaling pathway
GO:0019901	IDA	protein kinase binding
GO:0020037	IDA	heme binding
GO:0022408	IEA	negative regulation of cell-cell adhesion
GO:0030041	NAS	actin filament polymerization
GO:0030099	IEA	myeloid cell differentiation
GO:0030154	ISS	cell differentiation
GO:0030218	ISS	erythrocyte differentiation
GO:0030335	IEA	positive regulation of cell migration
GO:0031103	IEA	axon regeneration
GO:0031702	IEA	type 1 angiotensin receptor binding
GO:0031904	TAS	endosome lumen
GO:0031959	IEA	mineralocorticoid receptor signaling pathway
GO:0032024	IEA	positive regulation of insulin secretion
GO:0032496	ISS	response to lipopolysaccharide
GO:0032516	IEA	positive regulation of phosphoprotein phosphatase activity
GO:0032731	IEA	positive regulation of interleukin-1 beta production
GO:0032760	ISS	positive regulation of tumor necrosis factor production
GO:0033130	IEA	acetylcholine receptor binding
GO:0033160	IEA	positive regulation of protein import into nucleus, translocation
GO:0033194	IEA	response to hydroperoxide
GO:0033209	IDA	tumor necrosis factor-mediated signaling pathway
GO:0034050	IEA	host programmed cell death induced by symbiont
GO:0034612	IDA	response to tumor necrosis factor
GO:0035401	IDA	histone kinase activity (H3-Y41 specific)
GO:0035409	IDA	histone H3-Y41 phosphorylation
GO:0035556	ISS:IEA	intracellular signal transduction
GO:0035722	IDA	interleukin-12-mediated signaling pathway
GO:0042169	IPI	SH2 domain binding
GO:0042393	IDA	histone binding
GO:0042503	IEA	tyrosine phosphorylation of Stat3 protein
GO:0042506	IEA	tyrosine phosphorylation of Stat5 protein
GO:0042508	IEA	tyrosine phosphorylation of Stat1 protein
GO:0042517	ISS	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	ISS	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042977	ISS	activation of JAK2 kinase activity
GO:0043065	IEA	positive regulation of apoptotic process
GO:0043066	IEA	negative regulation of apoptotic process
GO:0043388	IEA	positive regulation of DNA binding
GO:0043392	ISS	negative regulation of DNA binding
GO:0043524	IEA	negative regulation of neuron apoptotic process
GO:0043548	IEA	phosphatidylinositol 3-kinase binding
GO:0043560	IEA	insulin receptor substrate binding
GO:0045121	ISS	membrane raft
GO:0045429	IEA	positive regulation of nitric oxide biosynthetic process
GO:0045597	IEA	positive regulation of cell differentiation
GO:0045822	IEA	negative regulation of heart contraction
GO:0045944	IEA	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	IDA	response to antibiotic
GO:0046777	ISS	protein autophosphorylation
GO:0048008	IEA	platelet-derived growth factor receptor signaling pathway
GO:0050727	IDA	regulation of inflammatory response
GO:0050729	IEA	positive regulation of inflammatory response
GO:0050731	ISS	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050867	IEA	positive regulation of cell activation
GO:0051091	IEA	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051428	IEA	peptide hormone receptor binding
GO:0051770	ISS	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333	TAS	interferon-gamma-mediated signaling pathway
GO:0060334	TAS	regulation of interferon-gamma-mediated signaling pathway
GO:0060396	IDA	growth hormone receptor signaling pathway
GO:0060397	ISS	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060399	ISS	positive regulation of growth hormone receptor signaling pathway
GO:0061180	ISS	mammary gland epithelium development
GO:0070671	IDA	response to interleukin-12
GO:0097191	ISS	extrinsic apoptotic signaling pathway
GO:0097296	ISS	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001235	IEA	positive regulation of apoptotic signaling pathway

Gene Ontology

GO ID

Evidence Type

GO Description

GO:0000186

IEA

activation of MAPKK activity

GO:0004672

NAS:IEA

protein kinase activity

GO:0004713

ISS:IEA

protein tyrosine kinase activity

GO:0004715

IEA

non-membrane spanning protein tyrosine kinase activity

GO:0005102

IPI

receptor binding

GO:0005131

ISS

growth hormone receptor binding

GO:0005143

ISS

interleukin-12 receptor binding

GO:0005515

IPI

protein binding

GO:0005524

IEA

ATP binding

GO:0005634

IDA

nucleus

GO:0005737

IDA

cytoplasm

GO:0005829

TAS

cytosol

GO:0005856

IEA

cytoskeleton

GO:0005901

ISS

caveola

GO:0006468

TAS:IEA

protein phosphorylation

GO:0006915

ISS

apoptotic process

GO:0006919

ISS

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO:0006928

TAS

cellular component movement

GO:0006979

IEA

response to oxidative stress

GO:0007165

ISS

signal transduction

GO:0007167

ISS

enzyme linked receptor protein signaling pathway

GO:0007186

IEA

G-protein coupled receptor signaling pathway

GO:0007204

IEA

positive regulation of cytosolic calcium ion concentration

GO:0007259

TAS

JAK-STAT cascade

GO:0007260

ISS

tyrosine phosphorylation of STAT protein

GO:0007262

ISS

STAT protein import into nucleus

GO:0007498

TAS

mesoderm development

GO:0007596

TAS

blood coagulation

GO:0008022

IEA

protein C-terminus binding

GO:0008284

IEA

positive regulation of cell proliferation

GO:0008285

ISS

negative regulation of cell proliferation

GO:0008631

IEA

intrinsic apoptotic signaling pathway in response to oxidative stress

GO:0009755

IEA

hormone-mediated signaling pathway

GO:0010811

IDA

positive regulation of cell-substrate adhesion

GO:0014068

ISS

positive regulation of phosphatidylinositol 3-kinase signaling

GO:0016020

IEA

membrane

GO:0016363

IEA

nuclear matrix

GO:0016772

IEA

transferase activity, transferring phosphorus-containing groups

GO:0018108

ISS

peptidyl-tyrosine phosphorylation

GO:0019221

ISS

cytokine-mediated signaling pathway

GO:0019901

IDA

protein kinase binding

GO:0020037

IDA

heme binding

GO:0022408

IEA

negative regulation of cell-cell adhesion

GO:0030041

NAS

actin filament polymerization

GO:0030099

IEA

myeloid cell differentiation

GO:0030154

ISS

cell differentiation

GO:0030218

ISS

erythrocyte differentiation

GO:0030335

IEA

positive regulation of cell migration

GO:0031103

IEA

axon regeneration

GO:0031702

IEA

type 1 angiotensin receptor binding

GO:0031904

TAS

endosome lumen

GO:0031959

IEA

mineralocorticoid receptor signaling pathway

GO:0032024

IEA

positive regulation of insulin secretion

GO:0032496

ISS

response to lipopolysaccharide

GO:0032516

IEA

positive regulation of phosphoprotein phosphatase activity

GO:0032731

IEA

positive regulation of interleukin-1 beta production

GO:0032760

ISS

positive regulation of tumor necrosis factor production

GO:0033130

IEA

acetylcholine receptor binding

GO:0033160

IEA

positive regulation of protein import into nucleus, translocation

GO:0033194

IEA

response to hydroperoxide

GO:0033209

IDA

tumor necrosis factor-mediated signaling pathway

GO:0034050

IEA

host programmed cell death induced by symbiont

GO:0034612

IDA

response to tumor necrosis factor

GO:0035401

IDA

histone kinase activity (H3-Y41 specific)

GO:0035409

IDA

histone H3-Y41 phosphorylation

GO:0035556

ISS:IEA

intracellular signal transduction

GO:0035722

IDA

interleukin-12-mediated signaling pathway

GO:0042169

IPI

SH2 domain binding

GO:0042393

IDA

histone binding

GO:0042503

IEA

tyrosine phosphorylation of Stat3 protein

GO:0042506

IEA

tyrosine phosphorylation of Stat5 protein

GO:0042508

IEA

tyrosine phosphorylation of Stat1 protein

GO:0042517

ISS

positive regulation of tyrosine phosphorylation of Stat3 protein

GO:0042523

ISS

positive regulation of tyrosine phosphorylation of Stat5 protein

GO:0042977

ISS

activation of JAK2 kinase activity

GO:0043065

IEA

positive regulation of apoptotic process

GO:0043066

IEA

negative regulation of apoptotic process

GO:0043388

IEA

positive regulation of DNA binding

GO:0043392

ISS

negative regulation of DNA binding

GO:0043524

IEA

negative regulation of neuron apoptotic process

GO:0043548

IEA

phosphatidylinositol 3-kinase binding

GO:0043560

IEA

insulin receptor substrate binding

GO:0045121

ISS

membrane raft

GO:0045429

IEA

positive regulation of nitric oxide biosynthetic process

GO:0045597

IEA

positive regulation of cell differentiation

GO:0045822

IEA

negative regulation of heart contraction

GO:0045944

IEA

positive regulation of transcription from RNA polymerase II promoter

GO:0046677

IDA

response to antibiotic

GO:0046777

ISS

protein autophosphorylation

GO:0048008

IEA

platelet-derived growth factor receptor signaling pathway

GO:0050727

IDA

regulation of inflammatory response

GO:0050729

IEA

positive regulation of inflammatory response

GO:0050731

ISS

positive regulation of peptidyl-tyrosine phosphorylation

GO:0050867

IEA

positive regulation of cell activation

GO:0051091

IEA

positive regulation of sequence-specific DNA binding transcription factor activity

GO:0051428

IEA

peptide hormone receptor binding

GO:0051770

ISS

positive regulation of nitric-oxide synthase biosynthetic process

GO:0060333

TAS

interferon-gamma-mediated signaling pathway

GO:0060334

TAS

regulation of interferon-gamma-mediated signaling pathway

GO:0060396

IDA

growth hormone receptor signaling pathway

GO:0060397

ISS

JAK-STAT cascade involved in growth hormone signaling pathway

GO:0060399

ISS

positive regulation of growth hormone receptor signaling pathway

GO:0061180

ISS

mammary gland epithelium development

GO:0070671

IDA

response to interleukin-12

GO:0097191

ISS

extrinsic apoptotic signaling pathway

GO:0097296

ISS

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO:2001235

IEA

positive regulation of apoptotic signaling pathway

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Code Context

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

Warning (512): _cake_core_ cache was unable to write 'method_cache' to File cache [CORE/Cake/Cache/Cache.php, line 323]

Code Context

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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000018882	jak2b	Janus kinase 2b	protein_coding	Danio_rerio
ENSMUSG00000024789	Jak2	Janus kinase 2	protein_coding	Mus_musculus

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Expression Patterns

Conserved Regions

Gene Ontology

Homologs

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