C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Janus kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000096968 JAK2 9606 + 9:4985033-5128183 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000381652 JAK2-001 4985245-5128183 protein_coding
  ENST00000476574 JAK2-002 4985033-5022065 processed_transcript
  ENST00000487310 JAK2-004 5125965-5126974 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000381652ENST00000487310
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000381652 4.178±0.00 3.797±0.00 0.493±0.00 2.476±0.94 3.696±1.17 1.963±0.00 6.641±0.00 2.685±0.00 2.282±1.81 7.536±3.60 1.453±0.06 1.695±1.00 1.256±0.52 5.147±0.57
ENST00000487310 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.019±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000NF CIL_0000NF_0001 CGP 9:4792834-5128183
CIL_0000NG CIL_0000NG_0001 CGP 9:4985033-5185668

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0004672 NAS:IEA protein kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005102 IPI receptor binding
GO:0005131 ISS growth hormone receptor binding
GO:0005143 ISS interleukin-12 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005901 ISS caveola
GO:0006468 TAS:IEA protein phosphorylation
GO:0006915 ISS apoptotic process
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928 TAS cellular component movement
GO:0006979 IEA response to oxidative stress
GO:0007165 ISS signal transduction
GO:0007167 ISS enzyme linked receptor protein signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007259 TAS JAK-STAT cascade
GO:0007260 ISS tyrosine phosphorylation of STAT protein
GO:0007262 ISS STAT protein import into nucleus
GO:0007498 TAS mesoderm development
GO:0007596 TAS blood coagulation
GO:0008022 IEA protein C-terminus binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755 IEA hormone-mediated signaling pathway
GO:0010811 IDA positive regulation of cell-substrate adhesion
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016363 IEA nuclear matrix
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0019901 IDA protein kinase binding
GO:0020037 IDA heme binding
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030041 NAS actin filament polymerization
GO:0030099 IEA myeloid cell differentiation
GO:0030154 ISS cell differentiation
GO:0030218 ISS erythrocyte differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0031103 IEA axon regeneration
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031904 TAS endosome lumen
GO:0031959 IEA mineralocorticoid receptor signaling pathway
GO:0032024 IEA positive regulation of insulin secretion
GO:0032496 ISS response to lipopolysaccharide
GO:0032516 IEA positive regulation of phosphoprotein phosphatase activity
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0033130 IEA acetylcholine receptor binding
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0033194 IEA response to hydroperoxide
GO:0033209 IDA tumor necrosis factor-mediated signaling pathway
GO:0034050 IEA host programmed cell death induced by symbiont
GO:0034612 IDA response to tumor necrosis factor
GO:0035401 IDA histone kinase activity (H3-Y41 specific)
GO:0035409 IDA histone H3-Y41 phosphorylation
GO:0035556 ISS:IEA intracellular signal transduction
GO:0035722 IDA interleukin-12-mediated signaling pathway
GO:0042169 IPI SH2 domain binding
GO:0042393 IDA histone binding
GO:0042503 IEA tyrosine phosphorylation of Stat3 protein
GO:0042506 IEA tyrosine phosphorylation of Stat5 protein
GO:0042508 IEA tyrosine phosphorylation of Stat1 protein
GO:0042517 ISS positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523 ISS positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042977 ISS activation of JAK2 kinase activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043388 IEA positive regulation of DNA binding
GO:0043392 ISS negative regulation of DNA binding
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0043560 IEA insulin receptor substrate binding
GO:0045121 ISS membrane raft
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045597 IEA positive regulation of cell differentiation
GO:0045822 IEA negative regulation of heart contraction
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046677 IDA response to antibiotic
GO:0046777 ISS protein autophosphorylation
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0050727 IDA regulation of inflammatory response
GO:0050729 IEA positive regulation of inflammatory response
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050867 IEA positive regulation of cell activation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051428 IEA peptide hormone receptor binding
GO:0051770 ISS positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060334 TAS regulation of interferon-gamma-mediated signaling pathway
GO:0060396 IDA growth hormone receptor signaling pathway
GO:0060397 ISS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060399 ISS positive regulation of growth hormone receptor signaling pathway
GO:0061180 ISS mammary gland epithelium development
GO:0070671 IDA response to interleukin-12
GO:0097191 ISS extrinsic apoptotic signaling pathway
GO:0097296 ISS activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018882 jak2b Janus kinase 2b protein_coding Danio_rerio
ENSMUSG00000024789 Jak2 Janus kinase 2 protein_coding Mus_musculus

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