C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Janus kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024789 Jak2 10090 + 19:29251828-29313080 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025705 Jak2-201 29251828-29313080 protein_coding
  ENSMUST00000065796 Jak2-202 29251828-29313080 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025705ENSMUST00000065796
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025705 N/A N/A N/A 5.034±0.00 1.443±0.00 N/A N/A N/A N/A N/A 2.755±0.00 4.617±2.31 5.560±0.73 N/A
ENSMUST00000065796 9.901±4.83 4.920±0.55 15.865±0.61 9.434±2.05 8.219±2.69 7.176±0.92 2.921±0.30 4.881±0.21 5.858±5.07 8.158±0.83 9.938±2.05 9.008±1.63 8.342±2.58 1.013±0.36

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000NF CIL_0000NF_0002 CGP 19:29101375-29313080
CIL_0000NG CIL_0000NG_0002 CGP 19:29251828-29325356

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005102 IEA receptor binding
GO:0005131 IEA growth hormone receptor binding
GO:0005143 IPI interleukin-12 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 TAS cytoplasm
GO:0005829 IEA cytosol
GO:0005856 IEA cytoskeleton
GO:0005901 IDA caveola
GO:0006979 IEA response to oxidative stress
GO:0007167 IDA enzyme linked receptor protein signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007259 IMP JAK-STAT cascade
GO:0007260 IMP tyrosine phosphorylation of STAT protein
GO:0007262 IDA STAT protein import into nucleus
GO:0008022 IEA protein C-terminus binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755 IEA hormone-mediated signaling pathway
GO:0010811 IEA positive regulation of cell-substrate adhesion
GO:0016363 IEA nuclear matrix
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019901 IEA protein kinase binding
GO:0020037 IEA heme binding
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030099 IMP myeloid cell differentiation
GO:0030154 IMP cell differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0031103 IEA axon regeneration
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0031959 IEA mineralocorticoid receptor signaling pathway
GO:0032024 IEA positive regulation of insulin secretion
GO:0032516 IEA positive regulation of phosphoprotein phosphatase activity
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0033130 IEA acetylcholine receptor binding
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0033194 IEA response to hydroperoxide
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0034050 IDA host programmed cell death induced by symbiont
GO:0034612 IEA response to tumor necrosis factor
GO:0035401 IEA histone kinase activity (H3-Y41 specific)
GO:0035409 IEA histone H3-Y41 phosphorylation
GO:0035556 IDA intracellular signal transduction
GO:0035722 IEA interleukin-12-mediated signaling pathway
GO:0042169 IEA SH2 domain binding
GO:0042393 IEA histone binding
GO:0042503 IEA tyrosine phosphorylation of Stat3 protein
GO:0042506 IEA tyrosine phosphorylation of Stat5 protein
GO:0042508 IEA tyrosine phosphorylation of Stat1 protein
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043388 IEA positive regulation of DNA binding
GO:0043392 IDA negative regulation of DNA binding
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0043560 IEA insulin receptor substrate binding
GO:0045121 IDA membrane raft
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045597 IEA positive regulation of cell differentiation
GO:0045822 IEA negative regulation of heart contraction
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046677 ISO response to antibiotic
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0050727 IEA regulation of inflammatory response
GO:0050729 IEA positive regulation of inflammatory response
GO:0050867 IEA positive regulation of cell activation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051428 IEA peptide hormone receptor binding
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 IEA interferon-gamma-mediated signaling pathway
GO:0060396 IEA growth hormone receptor signaling pathway
GO:0061180 IMP mammary gland epithelium development
GO:0070671 IEA response to interleukin-12
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:2001235 IMP positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018882 jak2b Janus kinase 2b protein_coding Danio_rerio
ENSG00000096968 JAK2 Janus kinase 2 protein_coding Homo_sapiens

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