C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein arginine methyltransferase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100462 PRMT5 9606 - 14:22920511-22929585 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216350 PRMT5-008 22920530-22929391 protein_coding
  ENST00000324366 PRMT5-003 22920511-22929585 protein_coding
  ENST00000397440 PRMT5-004 22920529-22929356 protein_coding
  ENST00000397441 PRMT5-007 22920525-22929401 protein_coding
  ENST00000421938 PRMT5-026 22926737-22929368 protein_coding
  ENST00000454731 PRMT5-022 22920825-22923162 protein_coding
  ENST00000476175 PRMT5-002 22920529-22922821 processed_transcript
  ENST00000553417 PRMT5-019 22926481-22927596 retained_intron
  ENST00000553502 PRMT5-017 22924162-22925046 protein_coding
  ENST00000553550 PRMT5-014 22924638-22929392 protein_coding
  ENST00000553641 PRMT5-024 22926133-22929351 processed_transcript
  ENST00000553787 PRMT5-025 22925000-22929373 nonsense_mediated_decay
  ENST00000553897 PRMT5-010 22920876-22929408 protein_coding
  ENST00000553915 PRMT5-009 22920857-22929365 nonsense_mediated_decay
  ENST00000554716 PRMT5-023 22924663-22929365 processed_transcript
  ENST00000554867 PRMT5-028 22926235-22929376 protein_coding
  ENST00000554910 PRMT5-015 22926275-22929081 protein_coding
  ENST00000555454 PRMT5-021 22920810-22924179 protein_coding
  ENST00000555530 PRMT5-020 22924317-22928143 protein_coding
  ENST00000556032 PRMT5-029 22927526-22929351 retained_intron
  ENST00000556043 PRMT5-018 22924499-22926456 protein_coding
  ENST00000556426 PRMT5-012 22928263-22929376 processed_transcript
  ENST00000556616 PRMT5-027 22926240-22929376 protein_coding
  ENST00000557015 PRMT5-011 22928131-22929394 retained_intron
  ENST00000557415 PRMT5-013 22926238-22929392 nonsense_mediated_decay
  ENST00000557443 PRMT5-006 22920529-22922240 protein_coding
  ENST00000557758 PRMT5-016 22922132-22922910 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000324366ENST00000397440ENST00000397441ENST00000454731ENST00000553417ENST00000553897ENST00000553915ENST00000555454ENST00000557415
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000324366 N/A N/A N/A 1.637±0.00 1.642±0.00 1.671±0.00 N/A 1.335±0.00 N/A N/A N/A 10.230±9.57 N/A 11.632±0.00
ENST00000397440 4.752±0.00 9.062±0.00 N/A N/A 6.926±0.00 N/A N/A N/A N/A 4.897±0.00 N/A N/A N/A N/A
ENST00000397441 3.686±0.00 N/A 1.221±0.00 7.320±0.00 2.374±0.00 10.700±0.00 4.914±0.00 17.519±0.00 9.126±0.00 3.613±0.00 14.839±0.00 10.107±0.49 4.143±0.00 16.180±0.00
ENST00000454731 N/A N/A 3.546±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000553417 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.132±0.00 N/A N/A N/A
ENST00000553897 N/A N/A N/A N/A 1.652±0.00 4.633±0.00 2.237±1.45 1.439±0.00 3.058±0.00 2.237±0.00 12.831±0.00 5.043±2.89 5.333±0.84 N/A
ENST00000553915 4.815±0.00 N/A N/A 7.768±0.00 3.758±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000555454 N/A N/A N/A N/A N/A N/A N/A 8.459±5.03 3.497±0.00 N/A N/A N/A N/A N/A
ENST00000557415 N/A N/A N/A N/A 9.566±0.00 N/A N/A N/A N/A N/A N/A N/A 7.266±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006WJ CIL_0006WJ_0001 CGP 14:22920511-22957161

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000387 IMP spliceosomal snRNP assembly
GO:0001046 ISS core promoter sequence-specific DNA binding
GO:0003682 IEA chromatin binding
GO:0003714 ISS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IBA regulation of transcription, DNA-templated
GO:0006479 IEA protein methylation
GO:0007088 TAS regulation of mitosis
GO:0008168 IEA:IDA methyltransferase activity
GO:0008283 TAS cell proliferation
GO:0008469 IBA histone-arginine N-methyltransferase activity
GO:0010467 TAS gene expression
GO:0016070 TAS RNA metabolic process
GO:0018216 IMP peptidyl-arginine methylation
GO:0019918 IMP peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032922 ISS circadian regulation of gene expression
GO:0034660 TAS ncRNA metabolic process
GO:0034709 IDA methylosome
GO:0035243 IMP protein-arginine omega-N symmetric methyltransferase activity
GO:0035246 IDA peptidyl-arginine N-methylation
GO:0042118 IMP endothelial cell activation
GO:0043021 IPI ribonucleoprotein complex binding
GO:0043234 IEA protein complex
GO:0043985 ISS histone H4-R3 methylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079605 prmt5 protein arginine methyltransferase 5 protein_coding Danio_rerio
ENSMUSG00000023110 Prmt5 protein arginine N-methyltransferase 5 protein_coding Mus_musculus

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