C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD40 ligand
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102245 CD40LG 9606 + X:136648193-136660390 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370628 CD40LG-002 136648227-136660390 protein_coding
  ENST00000370629 CD40LG-001 136648193-136660390 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370628ENST00000370629
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370628 N/A N/A 0.581±0.00 0.058±0.03 0.164±0.10 0.049±0.00 0.076±0.00 0.052±0.03 N/A 2.055±0.00 0.110±0.00 0.276±0.23 0.089±0.00 0.084±0.05
ENST00000370629 0.113±0.00 1.744±0.00 N/A N/A N/A 0.619±0.00 0.059±0.00 N/A 0.362±0.23 1.059±0.00 N/A 0.263±0.08 0.062±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JS CIL_0000JS_0001 CGP X:136532152-136660390
CIL_0000JT CIL_0000JT_0001 CGP X:136648193-136782088

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005125 IEA cytokine activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005174 IPI CD40 receptor binding
GO:0005515 IEA protein binding
GO:0005615 IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006954 IDA inflammatory response
GO:0006955 IEA immune response
GO:0007159 NAS leukocyte cell-cell adhesion
GO:0009897 IEA external side of plasma membrane
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0030168 IDA platelet activation
GO:0030183 IEA B cell differentiation
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0042100 IDA B cell proliferation
GO:0043066 IDA negative regulation of apoptotic process
GO:0045190 ISS isotype switching
GO:0048305 IEA immunoglobulin secretion
GO:0050776 TAS regulation of immune response
GO:0051023 IEA regulation of immunoglobulin secretion
GO:2000353 IDA positive regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031132 Cd40lg CD40 ligand protein_coding Mus_musculus

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