C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TNFRSF1A-associated via death domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102871 TRADD 9606 - 16:67154180-67160298 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345057 TRADD-001 67154180-67160298 protein_coding
  ENST00000486556 TRADD-002 67154199-67156249 protein_coding
  ENST00000563348 TRADD-005 67155539-67156681 retained_intron
  ENST00000566104 TRADD-003 67155751-67159898 processed_transcript
  ENST00000566247 TRADD-004 67154833-67155418 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345057ENST00000486556
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345057 8.687±0.00 9.800±0.00 N/A 6.947±0.00 11.693±9.85 11.109±0.00 4.536±0.00 28.026±0.00 5.865±4.46 11.268±9.45 6.622±0.00 18.657±8.55 17.430±5.18 12.217±0.00
ENST00000486556 2.463±0.00 4.041±0.00 0.674±0.00 1.892±0.00 N/A N/A 1.886±1.40 2.900±0.00 N/A 8.594±0.00 1.575±0.00 8.842±6.05 9.013±0.00 5.688±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WN CIL_0007WN_0001 VISTA 16:66603173-67205657
CIL_0005T5 CIL_0005T5_0001 CGP 16:67148105-67160298
CIL_0005T4 CIL_0005T4_0001 CGP 16:67154180-67164570

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004871 IEA signal transducer activity
GO:0005164 IEA tumor necrosis factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006915 TAS apoptotic process
GO:0006919 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 TAS:IEA signal transduction
GO:0008625 TAS extrinsic apoptotic signaling pathway via death domain receptors
GO:0019900 IPI kinase binding
GO:0031264 TAS death-inducing signaling complex
GO:0032403 IEA protein complex binding
GO:0033209 TAS tumor necrosis factor-mediated signaling pathway
GO:0042802 IPI identical protein binding
GO:0043065 TAS positive regulation of apoptotic process
GO:0043123 IEP:IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0043235 IDA receptor complex
GO:0045121 IEA membrane raft
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0051291 IEA protein heterooligomerization
GO:0051798 IEA positive regulation of hair follicle development
GO:0060090 IPI binding, bridging
GO:0070513 IPI death domain binding
GO:0097190 TAS apoptotic signaling pathway
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:2001239 TAS regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036057 tradd tnfrsf1a-associated via death domain protein_coding Danio_rerio
ENSMUSG00000031887 Tradd TNFRSF1A-associated via death domain protein_coding Mus_musculus

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