C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102882 MAPK3 9606 - 16:30114105-30123506 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263025 MAPK3-001 30114105-30123294 protein_coding
  ENST00000322266 MAPK3-201 30114106-30123309 protein_coding
  ENST00000395199 MAPK3-006 30116837-30123209 protein_coding
  ENST00000395200 MAPK3-011 30116635-30123150 protein_coding
  ENST00000395202 MAPK3-004 30116668-30123209 protein_coding
  ENST00000461737 MAPK3-012 30114546-30117286 nonsense_mediated_decay
  ENST00000466521 MAPK3-002 30114105-30123294 nonsense_mediated_decay
  ENST00000473431 MAPK3-013 30116635-30117105 retained_intron
  ENST00000478356 MAPK3-009 30116689-30122990 protein_coding
  ENST00000481230 MAPK3-007 30118103-30123506 protein_coding
  ENST00000483869 MAPK3-008 30117898-30123105 retained_intron
  ENST00000484663 MAPK3-003 30114106-30122968 protein_coding
  ENST00000485579 MAPK3-014 30114202-30116867 retained_intron
  ENST00000490298 MAPK3-005 30114120-30123227 nonsense_mediated_decay
  ENST00000494643 MAPK3-015 30114616-30115999 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000263025ENST00000395199ENST00000395200ENST00000395202ENST00000461737ENST00000473431ENST00000478356ENST00000481230ENST00000484663ENST00000490298
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000263025 54.358±0.00 41.133±0.00 0.316±0.00 53.852±0.00 21.667±20.64 20.351±19.55 9.400±0.00 14.783±0.00 N/A 67.920±0.00 54.705±6.95 82.142±29.00 39.333±0.00
ENST00000395199 N/A N/A 0.683±0.00 4.354±0.00 3.333±0.00 1.479±0.00 1.072±0.00 2.257±0.00 1.019±0.00 1.957±0.00 20.362±0.00 N/A N/A
ENST00000395200 N/A N/A N/A 14.393±9.45 1.283±0.00 2.346±0.00 N/A N/A 1.745±0.00 N/A 14.576±0.00 N/A 5.418±0.00
ENST00000395202 29.596±0.00 N/A N/A 4.736±0.00 23.488±0.00 7.631±5.51 N/A 1.486±0.00 N/A 1.237±0.00 17.948±0.00 N/A 22.622±0.00
ENST00000461737 30.858±0.00 43.495±0.00 N/A N/A 26.176±0.00 10.309±8.27 N/A N/A N/A N/A 30.056±0.33 31.611±0.00 N/A
ENST00000473431 N/A N/A N/A N/A N/A N/A N/A N/A 2.192±0.00 N/A N/A N/A 17.145±0.00
ENST00000478356 N/A N/A N/A N/A N/A N/A 6.339±0.00 4.829±3.82 3.636±0.00 N/A 21.812±0.00 N/A N/A
ENST00000481230 N/A N/A 3.295±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000484663 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.600±0.00 N/A N/A
ENST00000490298 N/A N/A 0.417±0.00 N/A N/A N/A 0.563±0.00 N/A 0.727±0.00 N/A 0.558±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA:NAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0001784 IEA phosphotyrosine binding
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004707 IEA:NAS MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 TAS cytoskeleton
GO:0005901 TAS caveola
GO:0005925 TAS focal adhesion
GO:0006351 IEA transcription, DNA-templated
GO:0006360 TAS transcription from RNA polymerase I promoter
GO:0006361 TAS transcription initiation from RNA polymerase I promoter
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0007049 IEA cell cycle
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009887 IEA organ morphogenesis
GO:0010467 TAS gene expression
GO:0015630 IDA microtubule cytoskeleton
GO:0016032 IEA viral process
GO:0016310 IDA phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019233 IEA sensory perception of pain
GO:0019902 IPI phosphatase binding
GO:0030168 TAS platelet activation
GO:0030509 IMP BMP signaling pathway
GO:0031143 IEA pseudopodium
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032496 IEA response to lipopolysaccharide
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0033129 IMP positive regulation of histone phosphorylation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035066 IMP positive regulation of histone acetylation
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038083 IDA peptidyl-tyrosine autophosphorylation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043330 IEA response to exogenous dsRNA
GO:0045087 TAS innate immune response
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051216 IEA cartilage development
GO:0051403 TAS stress-activated MAPK cascade
GO:0051493 TAS regulation of cytoskeleton organization
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070849 IDA response to epidermal growth factor
GO:0071260 IEP cellular response to mechanical stimulus
GO:0072584 TAS caveolin-mediated endocytosis
GO:0090170 TAS regulation of Golgi inheritance
GO:2000641 TAS regulation of early endosome to late endosome transport
GO:2000657 IEA negative regulation of apolipoprotein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070573 mapk3 mitogen-activated protein kinase 3 protein_coding Danio_rerio
ENSMUSG00000063065 Mapk3 mitogen-activated protein kinase 3 protein_coding Mus_musculus

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