C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000103266 STUB1 9606 + 16:680224-682870 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000219548 STUB1-001 680276-682799 protein_coding
  ENST00000563505 STUB1-007 680430-682066 retained_intron
  ENST00000564316 STUB1-011 681481-682746 protein_coding
  ENST00000564370 STUB1-008 681037-682496 protein_coding
  ENST00000565677 STUB1-002 680224-682746 protein_coding
  ENST00000565813 STUB1-012 682416-682870 nonsense_mediated_decay
  ENST00000566181 STUB1-005 681224-682213 processed_transcript
  ENST00000566408 STUB1-010 681276-682462 protein_coding
  ENST00000567173 STUB1-004 680424-682193 protein_coding
  ENST00000567790 STUB1-006 680439-681390 retained_intron
  ENST00000569248 STUB1-003 680419-682717 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000219548ENST00000563505ENST00000564370ENST00000566181ENST00000566408ENST00000567173
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000219548 N/A N/A N/A 7.921±0.00 N/A N/A 1.938±0.00 4.180±0.00 N/A 1.834±0.00 12.248±0.00 2.898±0.00 N/A N/A
ENST00000563505 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 61.528±0.00 11.478±0.00 N/A
ENST00000564370 N/A N/A N/A 23.791±0.00 16.747±11.62 23.652±0.00 N/A N/A 6.007±0.00 N/A 25.399±0.00 47.429±0.00 28.291±14.21 N/A
ENST00000566181 N/A N/A 8.925±0.00 N/A N/A 10.128±0.00 N/A N/A 17.826±0.00 N/A 29.655±0.00 33.098±0.00 30.235±0.00 35.387±0.00
ENST00000566408 N/A N/A 7.998±0.00 16.516±0.00 N/A N/A N/A 5.999±0.00 N/A 4.906±0.00 9.062±0.00 N/A N/A N/A
ENST00000567173 41.818±0.00 58.397±0.00 N/A 46.719±33.10 35.703±30.59 34.225±28.84 29.054±25.92 42.328±34.46 26.142±0.00 50.596±0.00 54.344±0.00 4.711±0.00 N/A 61.212±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IDA ubiquitin ligase complex
GO:0000209 IDA protein polyubiquitination
GO:0001664 IPI G-protein coupled receptor binding
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006281 IEA DNA repair
GO:0006511 IMP ubiquitin-dependent protein catabolic process
GO:0006515 IDA misfolded or incompletely synthesized protein catabolic process
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019899 IPI enzyme binding
GO:0019900 IPI kinase binding
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030544 IDA Hsp70 protein binding
GO:0030579 IDA ubiquitin-dependent SMAD protein catabolic process
GO:0030674 TAS protein binding, bridging
GO:0030911 IDA TPR domain binding
GO:0030968 IEA endoplasmic reticulum unfolded protein response
GO:0031371 TAS ubiquitin conjugating enzyme complex
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031943 IDA regulation of glucocorticoid metabolic process
GO:0032091 IEA negative regulation of protein binding
GO:0032436 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034450 ISS ubiquitin-ubiquitin ligase activity
GO:0042405 IDA nuclear inclusion body
GO:0042803 ISS protein homodimerization activity
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045111 IDA intermediate filament cytoskeleton
GO:0046332 IDA SMAD binding
GO:0051443 IEA positive regulation of ubiquitin-protein transferase activity
GO:0051604 TAS protein maturation
GO:0051787 IDA misfolded protein binding
GO:0051865 IDA protein autoubiquitination
GO:0051879 IDA Hsp90 protein binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070534 IDA protein K63-linked ubiquitination
GO:0071218 IDA cellular response to misfolded protein
GO:0090035 IDA positive regulation of chaperone-mediated protein complex assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045228 stub1 STIP1 homology and U-Box containing protein 1 protein_coding Danio_rerio
ENSMUSG00000039615 Stub1 STIP1 homology and U-Box containing protein 1 protein_coding Mus_musculus

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