C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: PYD and CARD domain containing
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000103490 PYCARD 9606 - 16:31201485-31203450 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000247470 PYCARD-001 31201485-31202992 protein_coding
  ENST00000350605 PYCARD-002 31201486-31202756 protein_coding
  ENST00000561508 PYCARD-003 31202194-31203450 protein_coding
  ENST00000565022 PYCARD-004 31201486-31202440 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000247470ENST00000350605ENST00000565022
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000247470 6.944±0.00 10.056±0.00 1.329±0.00 0.772±0.00 3.165±2.60 2.522±1.48 1.526±0.00 3.404±0.00 4.047±0.00 6.623±0.00 N/A 6.370±4.14 11.007±2.95 2.978±2.71
ENST00000350605 9.683±0.00 20.728±0.00 N/A 1.909±0.00 11.726±0.00 6.165±0.00 0.662±0.00 3.521±0.00 N/A 12.147±0.00 1.959±0.00 9.155±0.00 4.874±1.84 7.143±0.00
ENST00000565022 N/A 6.347±0.00 N/A 0.597±0.00 1.614±0.00 6.436±0.32 0.217±0.15 N/A 0.793±0.00 2.054±0.00 1.602±0.76 6.214±2.45 3.532±0.03 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00035T CIL_00035T_0001 CGP 16:31201485-31226427

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001773 IMP myeloid dendritic cell activation
GO:0002020 IEA protease binding
GO:0002218 IDA activation of innate immune response
GO:0002230 IEA positive regulation of defense response to virus by host
GO:0002277 ISS myeloid dendritic cell activation involved in immune response
GO:0002588 ISS positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002821 IMP positive regulation of adaptive immune response
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005634 ISS nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006915 TAS apoptotic process
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 IEA inflammatory response
GO:0007165 NAS signal transduction
GO:0008385 TAS IkappaB kinase complex
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009617 IEA response to bacterium
GO:0010506 IEA regulation of autophagy
GO:0010803 IMP regulation of tumor necrosis factor-mediated signaling pathway
GO:0030838 ISS positive regulation of actin filament polymerization
GO:0031647 ISS regulation of protein stability
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032090 IPI Pyrin domain binding
GO:0032314 IEA regulation of Rac GTPase activity
GO:0032611 IEA interleukin-1 beta production
GO:0032688 IMP negative regulation of interferon-beta production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032755 ISS positive regulation of interleukin-6 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0033209 IDA tumor necrosis factor-mediated signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042104 ISS positive regulation of activated T cell proliferation
GO:0042771 IMP intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043025 IEA neuronal cell body
GO:0043065 IDA positive regulation of apoptotic process
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044325 IEA ion channel binding
GO:0044351 ISS macropinocytosis
GO:0045087 TAS innate immune response
GO:0046330 IMP positive regulation of JNK cascade
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050727 IEA regulation of inflammatory response
GO:0050766 ISS positive regulation of phagocytosis
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0050870 IMP positive regulation of T cell activation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IDA defense response to virus
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071347 IDA cellular response to interleukin-1
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:0072332 IMP intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072558 IDA NLRP1 inflammasome complex
GO:0072559 IDA NLRP3 inflammasome complex
GO:0090197 IMP positive regulation of chemokine secretion
GO:0090200 IDA positive regulation of release of cytochrome c from mitochondria
GO:0097169 IDA AIM2 inflammasome complex
GO:2000406 ISS positive regulation of T cell migration
GO:2000484 IMP positive regulation of interleukin-8 secretion
GO:2000778 IMP positive regulation of interleukin-6 secretion
GO:2001056 IDA positive regulation of cysteine-type endopeptidase activity
GO:2001181 IMP positive regulation of interleukin-10 secretion
GO:2001238 IDA positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 IDA regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040076 pycard PYD and CARD domain containing protein_coding Danio_rerio
ENSMUSG00000030793 Pycard PYD and CARD domain containing protein_coding Mus_musculus

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