C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: PYD and CARD domain containing
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030793 Pycard 10090 - 7:127992103-127993867 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033056 Pycard-001 127992103-127993867 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033056
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033056 10.656±5.96 3.106±0.75 18.039±1.54 1.114±0.59 18.755±4.86 96.028±22.83 3.958±2.07 11.775±1.98 3.443±2.90 10.620±0.83 0.298±0.24 14.851±6.74 2.822±2.74 0.749±0.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00035T CIL_00035T_0002 CGP 7:127992103-128011393

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001773 IEA myeloid dendritic cell activation
GO:0002020 IEA protease binding
GO:0002218 IMP activation of innate immune response
GO:0002230 IMP positive regulation of defense response to virus by host
GO:0002277 IMP myeloid dendritic cell activation involved in immune response
GO:0002588 IMP positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002821 IEA positive regulation of adaptive immune response
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005829 IDA cytosol
GO:0006915 ISO apoptotic process
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 IMP inflammatory response
GO:0009617 IMP response to bacterium
GO:0010506 IMP regulation of autophagy
GO:0010803 IEA regulation of tumor necrosis factor-mediated signaling pathway
GO:0016505 ISO peptidase activator activity involved in apoptotic process
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0031647 IMP regulation of protein stability
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032090 ISS Pyrin domain binding
GO:0032314 IMP regulation of Rac GTPase activity
GO:0032611 IGI interleukin-1 beta production
GO:0032688 IEA negative regulation of interferon-beta production
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0042104 IMP positive regulation of activated T cell proliferation
GO:0042771 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 ISS protein homodimerization activity
GO:0042981 IMP regulation of apoptotic process
GO:0043025 IEA neuronal cell body
GO:0043065 IEA positive regulation of apoptotic process
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 IMP regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044325 IEA ion channel binding
GO:0044351 IMP macropinocytosis
GO:0045087 IEA innate immune response
GO:0046330 IEA positive regulation of JNK cascade
GO:0050718 ISS positive regulation of interleukin-1 beta secretion
GO:0050727 IMP regulation of inflammatory response
GO:0050766 IMP positive regulation of phagocytosis
GO:0050829 IEA defense response to Gram-negative bacterium
GO:0050870 IEA positive regulation of T cell activation
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IEA defense response to virus
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071347 IEA cellular response to interleukin-1
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:0072332 IEA intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072558 IEA NLRP1 inflammasome complex
GO:0072559 ISS NLRP3 inflammasome complex
GO:0090197 IMP positive regulation of chemokine secretion
GO:0090200 IEA positive regulation of release of cytochrome c from mitochondria
GO:0097169 ISS AIM2 inflammasome complex
GO:2000406 IMP positive regulation of T cell migration
GO:2000484 IEA positive regulation of interleukin-8 secretion
GO:2000778 IEA positive regulation of interleukin-6 secretion
GO:2001056 IEA positive regulation of cysteine-type endopeptidase activity
GO:2001181 IEA positive regulation of interleukin-10 secretion
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 IEA regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040076 pycard PYD and CARD domain containing protein_coding Danio_rerio
ENSG00000103490 PYCARD PYD and CARD domain containing protein_coding Homo_sapiens

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