C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: c-src tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000103653 CSK 9606 + 15:74782057-74803198 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000220003 CSK-001 74782057-74803198 protein_coding
  ENST00000439220 CSK-002 74782089-74802882 protein_coding
  ENST00000562066 CSK-009 74798436-74799398 retained_intron
  ENST00000563010 CSK-014 74801630-74802597 retained_intron
  ENST00000563894 CSK-005 74782504-74799051 retained_intron
  ENST00000564216 CSK-013 74800475-74802557 retained_intron
  ENST00000566464 CSK-011 74800489-74801729 retained_intron
  ENST00000567123 CSK-015 74782592-74799471 protein_coding
  ENST00000567135 CSK-010 74799178-74801823 retained_intron
  ENST00000567571 CSK-006 74788544-74803171 protein_coding
  ENST00000568329 CSK-007 74798652-74802589 retained_intron
  ENST00000569321 CSK-012 74800852-74802030 retained_intron
  ENST00000569462 CSK-016 74782605-74799361 protein_coding
  ENST00000569915 CSK-008 74797914-74798890 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000220003ENST00000439220ENST00000564216ENST00000566464ENST00000567123ENST00000567135ENST00000567571ENST00000568329ENST00000569462
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000220003 9.082±0.00 43.741±0.00 N/A 2.518±0.00 2.459±1.70 4.781±0.00 2.582±2.48 7.027±0.00 14.198±0.00 9.581±0.00 1.923±0.00 13.184±9.18 11.889±3.47 9.595±3.43
ENST00000439220 9.079±0.00 42.085±0.00 N/A 6.978±0.00 6.965±0.00 2.899±2.18 6.243±0.00 9.966±0.00 3.588±2.33 15.217±0.00 2.862±0.00 12.937±6.55 11.177±2.21 8.170±5.11
ENST00000564216 N/A N/A N/A N/A N/A N/A 0.255±0.00 N/A N/A N/A N/A N/A 5.600±0.00 N/A
ENST00000566464 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.090±0.00 N/A N/A N/A
ENST00000567123 N/A N/A N/A N/A 1.734±0.00 1.961±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000567135 N/A N/A 1.573±0.00 N/A 1.148±0.00 N/A N/A N/A 1.134±0.00 N/A 1.713±0.00 53.833±0.00 11.784±0.00 11.148±0.00
ENST00000567571 N/A N/A N/A 0.397±0.00 0.409±0.00 0.688±0.00 N/A 0.379±0.00 N/A N/A N/A N/A N/A N/A
ENST00000568329 N/A N/A N/A N/A N/A 1.963±0.00 0.393±0.00 1.133±0.00 N/A 1.937±0.00 N/A 10.881±7.81 N/A N/A
ENST00000569462 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.768±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UD CIL_0007UD_0001 VISTA 15:74278506-74880453

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IPI plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006468 TAS:IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007420 IEA brain development
GO:0007596 TAS blood coagulation
GO:0008022 TAS protein C-terminus binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0010989 IEA negative regulation of low-density lipoprotein particle clearance
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019903 IEA protein phosphatase binding
GO:0030168 TAS platelet activation
GO:0031295 TAS T cell costimulation
GO:0032715 IEA negative regulation of interleukin-6 production
GO:0033673 IEA negative regulation of kinase activity
GO:0034332 IEA adherens junction organization
GO:0042802 IPI identical protein binding
GO:0042997 IDA negative regulation of Golgi to plasma membrane protein transport
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0045121 IEA membrane raft
GO:0045779 IEA negative regulation of bone resorption
GO:0046777 IEA protein autophosphorylation
GO:0048709 IEA oligodendrocyte differentiation
GO:0050765 IEA negative regulation of phagocytosis
GO:0050852 TAS T cell receptor signaling pathway
GO:0060368 IEA regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070064 IEA proline-rich region binding
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:0071375 IEA cellular response to peptide hormone stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067996 CSK (1 of 2) c-src tyrosine kinase protein_coding Danio_rerio
ENSDARG00000070805 csk c-src tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000032312 Csk c-src tyrosine kinase protein_coding Mus_musculus

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