C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000103657 HERC1 9606 - 15:63608618-63833942 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000443617 HERC1-001 63608618-63833888 protein_coding
  ENST00000558324 HERC1-012 63622838-63630551 nonsense_mediated_decay
  ENST00000558532 HERC1-005 63775165-63833917 protein_coding
  ENST00000559715 HERC1-014 63674741-63677986 protein_coding
  ENST00000559886 HERC1-002 63752515-63833917 retained_intron
  ENST00000559996 HERC1-013 63615781-63616732 retained_intron
  ENST00000560316 HERC1-004 63775564-63833885 protein_coding
  ENST00000560462 HERC1-015 63775188-63833915 protein_coding
  ENST00000560519 HERC1-006 63734643-63749449 retained_intron
  ENST00000560897 HERC1-008 63633963-63637550 nonsense_mediated_decay
  ENST00000560983 HERC1-007 63718429-63723257 retained_intron
  ENST00000561348 HERC1-011 63624281-63630697 retained_intron
  ENST00000561359 HERC1-010 63630532-63633876 nonsense_mediated_decay
  ENST00000561400 HERC1-003 63696124-63833942 protein_coding
  ENST00000561436 HERC1-009 63630520-63634941 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000443617ENST00000561400
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000443617 1.249±0.00 1.318±0.00 2.452±0.00 6.161±3.47 1.419±0.00 2.274±1.13 2.923±1.05 3.353±0.00 3.408±2.30 4.203±2.12 2.007±1.36 0.525±0.03 2.190±0.00
ENST00000561400 N/A N/A N/A 11.201±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00050A CIL_00050A_0002 CGP 15:63608618-64072033

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005086 TAS ARF guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IEA protein binding
GO:0005737 TAS cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0006810 IEA transport
GO:0010507 IEA negative regulation of autophagy
GO:0016020 IEA membrane
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0021702 IEA cerebellar Purkinje cell differentiation
GO:0031175 IEA neuron projection development
GO:0043547 IEA positive regulation of GTPase activity
GO:0050885 IEA neuromuscular process controlling balance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077901 HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 protein_coding Danio_rerio
ENSMUSG00000038664 Herc1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 protein_coding Mus_musculus

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