C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secreted frizzled-related protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104332 SFRP1 9606 - 8:41261958-41309497 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000220772 SFRP1-001 41261958-41309497 protein_coding
  ENST00000379845 SFRP1-003 41261964-41306990 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000220772ENST00000379845
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000220772 12.384±0.00 7.437±0.00 10.047±0.00 5.104±4.36 48.061±41.28 14.309±13.15 8.256±3.26 69.260±0.00 4.838±3.96 2.448±1.22 0.867±0.71 20.933±20.60 18.393±8.87 33.083±20.07
ENST00000379845 N/A N/A 2.556±0.00 1.264±0.00 N/A 2.486±0.00 N/A 0.426±0.00 N/A 0.879±0.00 N/A 0.078±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003YP CIL_0003YP_0002 CGP 8:40530590-41309497
CIL_0005LU CIL_0005LU_0002 CGP 8:41261958-41510980

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IEP osteoblast differentiation
GO:0001657 IEA ureteric bud development
GO:0001756 IEA somitogenesis
GO:0001843 IEA neural tube closure
GO:0001944 IBA vasculature development
GO:0001954 ISS positive regulation of cell-matrix adhesion
GO:0002244 IDA hematopoietic progenitor cell differentiation
GO:0004197 IMP cysteine-type endopeptidase activity
GO:0005109 IPI frizzled binding
GO:0005515 IPI:IEA protein binding
GO:0005576 IEA extracellular region
GO:0005578 IDA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005622 IDA intracellular
GO:0005829 IDA cytosol
GO:0005886 ISS plasma membrane
GO:0006508 IMP proteolysis
GO:0007420 IBA brain development
GO:0008144 IDA drug binding
GO:0008201 IDA heparin binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008406 IBA gonad development
GO:0008584 IEA male gonad development
GO:0008585 IEA female gonad development
GO:0009267 IEP cellular response to starvation
GO:0009950 IDA dorsal/ventral axis specification
GO:0009952 IEA anterior/posterior pattern specification
GO:0009986 IDA cell surface
GO:0010564 IMP regulation of cell cycle process
GO:0010629 IDA negative regulation of gene expression
GO:0010719 IDA negative regulation of epithelial to mesenchymal transition
GO:0014034 IEA neural crest cell fate commitment
GO:0014070 IDA response to organic cyclic compound
GO:0017147 IPI Wnt-protein binding
GO:0021915 IEA neural tube development
GO:0022601 IEP menstrual cycle phase
GO:0030097 IEA hemopoiesis
GO:0030165 IBA PDZ domain binding
GO:0030177 IDA positive regulation of Wnt signaling pathway
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030279 IDA negative regulation of ossification
GO:0030307 IDA positive regulation of cell growth
GO:0030308 IDA negative regulation of cell growth
GO:0030336 IDA negative regulation of cell migration
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0031012 IDA extracellular matrix
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0035019 IEA somatic stem cell maintenance
GO:0042493 IDA response to drug
GO:0042802 IPI identical protein binding
GO:0042813 IBA Wnt-activated receptor activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043508 IEA negative regulation of JUN kinase activity
GO:0044344 IDA cellular response to fibroblast growth factor stimulus
GO:0044345 IEA stromal-epithelial cell signaling involved in prostate gland development
GO:0045578 IMP negative regulation of B cell differentiation
GO:0045600 IDA positive regulation of fat cell differentiation
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045671 IEA negative regulation of osteoclast differentiation
GO:0045765 ISS regulation of angiogenesis
GO:0045880 IMP positive regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046546 IEA development of primary male sexual characteristics
GO:0046676 IDA negative regulation of insulin secretion
GO:0046851 IMP negative regulation of bone remodeling
GO:0048147 IDA negative regulation of fibroblast proliferation
GO:0048546 IEA digestive tract morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050680 IDA negative regulation of epithelial cell proliferation
GO:0050732 IDA negative regulation of peptidyl-tyrosine phosphorylation
GO:0051496 ISS positive regulation of stress fiber assembly
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060071 IEA Wnt signaling pathway, planar cell polarity pathway
GO:0060218 IDA hematopoietic stem cell differentiation
GO:0060346 IEA bone trabecula formation
GO:0060527 IEA prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 IEA regulation of branching involved in prostate gland morphogenesis
GO:0060766 IDA negative regulation of androgen receptor signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071305 IEP cellular response to vitamin D
GO:0071347 IEP cellular response to interleukin-1
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071380 IEP cellular response to prostaglandin E stimulus
GO:0071391 IDA cellular response to estrogen stimulus
GO:0071392 IEP cellular response to estradiol stimulus
GO:0071456 IEP cellular response to hypoxia
GO:0071481 IEA cellular response to X-ray
GO:0071504 IDA cellular response to heparin
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0071773 IEP cellular response to BMP stimulus
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0090175 IEA regulation of establishment of planar polarity
GO:0090179 IEA planar cell polarity pathway involved in neural tube closure
GO:0090244 IEA Wnt signaling pathway involved in somitogenesis
GO:0090246 IEA convergent extension involved in somitogenesis
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway
GO:1902043 IDA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041 IEA negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052 IDA positive regulation of non-canonical Wnt signaling pathway
GO:2000054 IDA negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080 IDA negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270 IDA negative regulation of fibroblast apoptotic process
GO:2000271 IDA positive regulation of fibroblast apoptotic process
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035521 sfrp1a secreted frizzled-related protein 1a protein_coding Danio_rerio
ENSDARG00000057678 sfrp1b secreted frizzled-related protein 1b protein_coding Danio_rerio
ENSMUSG00000031548 Sfrp1 secreted frizzled-related protein 1 protein_coding Mus_musculus

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