C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secreted frizzled-related protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031548 Sfrp1 10090 + 8:23411502-23449632 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033952 Sfrp1-001 23411502-23449632 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033952
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033952 3.671±1.52 11.334±0.86 8.893±1.14 8.937±5.03 4.780±1.26 13.974±3.19 3.165±0.19 34.138±2.33 1.893±1.92 5.572±0.92 0.394±0.10 18.957±6.37 4.702±4.06 0.603±0.25

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003AU CIL_0003AU_0002 CGP 8:23411502-24156585

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001649 IEA osteoblast differentiation
GO:0001657 IEP ureteric bud development
GO:0001756 IEP somitogenesis
GO:0001843 IGI neural tube closure
GO:0001944 IBA vasculature development
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0004197 IEA cysteine-type endopeptidase activity
GO:0005109 IEA frizzled binding
GO:0005515 IPI protein binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IEA extracellular space
GO:0005622 IEA intracellular
GO:0005737 IBA cytoplasm
GO:0005829 IEA cytosol
GO:0005886 IBA plasma membrane
GO:0006357 IBA regulation of transcription from RNA polymerase II promoter
GO:0006508 IEA proteolysis
GO:0007420 IBA brain development
GO:0008144 IEA drug binding
GO:0008201 IEA heparin binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008584 IGI male gonad development
GO:0008585 IGI female gonad development
GO:0009267 IEA cellular response to starvation
GO:0009950 IEA dorsal/ventral axis specification
GO:0009952 IGI anterior/posterior pattern specification
GO:0009986 IEA cell surface
GO:0010564 IEA regulation of cell cycle process
GO:0010629 IMP negative regulation of gene expression
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0014034 IMP neural crest cell fate commitment
GO:0014070 IEA response to organic cyclic compound
GO:0017147 IPI Wnt-protein binding
GO:0021915 IGI neural tube development
GO:0022601 IEA menstrual cycle phase
GO:0030036 ISO actin cytoskeleton organization
GO:0030097 IMP hemopoiesis
GO:0030165 IBA PDZ domain binding
GO:0030177 IEA positive regulation of Wnt signaling pathway
GO:0030178 IGI negative regulation of Wnt signaling pathway
GO:0030279 IMP negative regulation of ossification
GO:0030307 IEA positive regulation of cell growth
GO:0030308 IEA negative regulation of cell growth
GO:0030336 IEA negative regulation of cell migration
GO:0030514 IGI negative regulation of BMP signaling pathway
GO:0031012 IEA extracellular matrix
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0034446 ISO substrate adhesion-dependent cell spreading
GO:0035019 IMP somatic stem cell maintenance
GO:0042493 IDA response to drug
GO:0042802 IEA identical protein binding
GO:0042813 IBA Wnt-activated receptor activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043508 IGI negative regulation of JUN kinase activity
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0044345 IEP stromal-epithelial cell signaling involved in prostate gland development
GO:0045578 IMP negative regulation of B cell differentiation
GO:0045600 ISO positive regulation of fat cell differentiation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0045671 IMP negative regulation of osteoclast differentiation
GO:0045880 IEA positive regulation of smoothened signaling pathway
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046546 IGI development of primary male sexual characteristics
GO:0046676 IEA negative regulation of insulin secretion
GO:0046851 IEA negative regulation of bone remodeling
GO:0048147 IEA negative regulation of fibroblast proliferation
GO:0048546 IGI digestive tract morphogenesis
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050732 IEA negative regulation of peptidyl-tyrosine phosphorylation
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060071 IDA Wnt signaling pathway, planar cell polarity pathway
GO:0060218 IEA hematopoietic stem cell differentiation
GO:0060346 IMP bone trabecula formation
GO:0060527 IMP prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 IMP regulation of branching involved in prostate gland morphogenesis
GO:0060766 IEA negative regulation of androgen receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0071305 IEA cellular response to vitamin D
GO:0071347 IEA cellular response to interleukin-1
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071380 IEA cellular response to prostaglandin E stimulus
GO:0071391 IDA cellular response to estrogen stimulus
GO:0071392 IEA cellular response to estradiol stimulus
GO:0071456 IEA cellular response to hypoxia
GO:0071481 IDA cellular response to X-ray
GO:0071504 IEA cellular response to heparin
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0071773 IEA cellular response to BMP stimulus
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0090175 IGI regulation of establishment of planar polarity
GO:0090179 IGI planar cell polarity pathway involved in neural tube closure
GO:0090244 IGI Wnt signaling pathway involved in somitogenesis
GO:0090246 IGI convergent extension involved in somitogenesis
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041 IGI negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052 IEA positive regulation of non-canonical Wnt signaling pathway
GO:2000054 IEA negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080 IEA negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270 IEA negative regulation of fibroblast apoptotic process
GO:2000271 IEA positive regulation of fibroblast apoptotic process
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035521 sfrp1a secreted frizzled-related protein 1a protein_coding Danio_rerio
ENSDARG00000057678 sfrp1b secreted frizzled-related protein 1b protein_coding Danio_rerio
ENSG00000104332 SFRP1 secreted frizzled-related protein 1 protein_coding Homo_sapiens

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