C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104814 MAP4K1 9606 - 19:38587641-38618882 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000396857 MAP4K1-001 38587669-38618003 protein_coding
  ENST00000585583 MAP4K1-005 38597348-38613927 nonsense_mediated_decay
  ENST00000586296 MAP4K1-004 38587644-38617966 protein_coding
  ENST00000587300 MAP4K1-007 38616178-38617969 retained_intron
  ENST00000588083 MAP4K1-008 38614067-38617845 retained_intron
  ENST00000588938 MAP4K1-013 38593271-38597093 retained_intron
  ENST00000589002 MAP4K1-012 38606186-38613927 processed_transcript
  ENST00000589130 MAP4K1-003 38587646-38618882 protein_coding
  ENST00000591210 MAP4K1-015 38587674-38593369 retained_intron
  ENST00000591517 MAP4K1-002 38587641-38617924 protein_coding
  ENST00000591707 MAP4K1-010 38611100-38614498 retained_intron
  ENST00000591921 MAP4K1-006 38587700-38609634 protein_coding
  ENST00000592225 MAP4K1-009 38614043-38614873 retained_intron
  ENST00000592888 MAP4K1-011 38611089-38614477 retained_intron
  ENST00000593196 MAP4K1-014 38587641-38595730 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000396857ENST00000585583ENST00000586296ENST00000587300ENST00000588083ENST00000588938ENST00000589002ENST00000589130ENST00000591517ENST00000591921ENST00000592225ENST00000592888ENST00000593196
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000396857 N/A 6.450±0.00 N/A N/A 0.877±0.00 0.562±0.00 0.037±0.00 N/A N/A 1.248±0.35 N/A 0.342±0.00 1.259±0.55 N/A
ENST00000585583 N/A N/A 0.435±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000586296 N/A N/A N/A 0.067±0.00 0.661±0.00 N/A 0.123±0.03 N/A N/A 1.121±0.00 N/A 0.233±0.04 N/A N/A
ENST00000587300 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.772±0.00 N/A N/A N/A
ENST00000588083 N/A N/A N/A N/A N/A 1.875±0.00 1.026±0.00 N/A 0.541±0.00 N/A N/A N/A N/A N/A
ENST00000588938 N/A N/A 0.242±0.00 1.026±0.00 N/A N/A N/A 2.258±0.00 N/A N/A N/A 0.494±0.00 N/A 0.821±0.00
ENST00000589002 N/A N/A N/A N/A N/A N/A 0.422±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000589130 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.264±0.00 1.039±0.13 N/A
ENST00000591517 0.572±0.00 5.823±0.00 N/A 0.427±0.00 1.612±0.00 N/A N/A 0.712±0.00 0.284±0.00 N/A N/A 0.271±0.06 1.052±0.59 0.379±0.00
ENST00000591921 0.291±0.00 13.524±0.00 N/A N/A N/A N/A N/A 0.783±0.00 0.120±0.03 2.290±0.00 0.893±0.00 N/A N/A 0.655±0.00
ENST00000592225 0.513±0.00 N/A N/A 0.685±0.00 1.677±0.00 2.187±0.00 N/A 0.660±0.00 0.566±0.00 N/A N/A N/A N/A N/A
ENST00000592888 N/A N/A N/A N/A N/A N/A 0.262±0.00 N/A 0.343±0.00 N/A N/A N/A N/A N/A
ENST00000593196 0.570±0.00 N/A N/A N/A N/A 0.608±0.00 N/A N/A N/A N/A N/A N/A N/A 2.655±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000185 IC activation of MAPKKK activity
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0006468 IEA protein phosphorylation
GO:0006950 IDA response to stress
GO:0007257 TAS activation of JUN kinase activity
GO:0008283 IMP cell proliferation
GO:0008349 IDA MAP kinase kinase kinase kinase activity
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0035556 IDA intracellular signal transduction
GO:0046777 IDA protein autophosphorylation
GO:0050790 IEA regulation of catalytic activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088216 MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 protein_coding Danio_rerio
ENSMUSG00000037337 Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 protein_coding Mus_musculus

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