C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DOT1-like histone H3K79 methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104885 DOT1L 9606 + 19:2164149-2232578 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000398665 DOT1L-001 2164149-2232578 protein_coding
  ENST00000446286 DOT1L-007 2226917-2227901 protein_coding
  ENST00000452696 DOT1L-003 2164185-2199928 protein_coding
  ENST00000457590 DOT1L-008 2222530-2230694 protein_coding
  ENST00000478937 DOT1L-004 2164198-2191305 nonsense_mediated_decay
  ENST00000482433 DOT1L-002 2216166-2222882 retained_intron
  ENST00000586024 DOT1L-009 2213590-2215867 protein_coding
  ENST00000591498 DOT1L-010 2212237-2214572 processed_transcript
  ENST00000608122 DOT1L-006 2214128-2216629 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000398665ENST00000452696
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000398665 2.647±0.00 6.469±0.00 0.744±0.00 1.285±0.83 1.792±0.46 1.470±0.88 0.950±0.81 5.290±0.00 1.403±1.02 7.162±0.00 1.560±1.30 4.329±2.16 5.859±1.79 16.602±4.71
ENST00000452696 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.752±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009F CIL_00009F_0001 CGP 19:2096429-2164465
CIL_00009C CIL_00009C_0001 CGP 19:2100988-2232578
CIL_0001T8 CIL_0001T8_0001 CGP 19:2164149-2237704

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0008134 IPI transcription factor binding
GO:0016571 IEA histone methylation
GO:0018024 IDA:IEA histone-lysine N-methyltransferase activity
GO:0034968 IEA histone lysine methylation
GO:0042054 IEA histone methyltransferase activity
GO:0046425 IDA regulation of JAK-STAT cascade
GO:2000677 IMP regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061992 dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000061589 Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) protein_coding Mus_musculus

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