C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061589 Dot1l 10090 + 10:80755206-80795461 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000105336 Dot1l-001 80755206-80795461 protein_coding
  ENSMUST00000127740 Dot1l-002 80755208-80794387 nonsense_mediated_decay
  ENSMUST00000138505 Dot1l-005 80791454-80793818 protein_coding
  ENSMUST00000147579 Dot1l-006 80755463-80766587 retained_intron
  ENSMUST00000149394 Dot1l-004 80789063-80794347 nonsense_mediated_decay
  ENSMUST00000150338 Dot1l-003 80777556-80794391 protein_coding
  ENSMUST00000163526 Dot1l-007 80785164-80786421 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000105336ENSMUST00000127740ENSMUST00000138505ENSMUST00000149394ENSMUST00000150338
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000105336 5.041±1.59 11.664±5.19 4.119±2.21 8.815±3.59 2.615±1.96 4.218±2.39 4.848±2.03 2.741±1.03 3.600±2.82 4.152±0.71 6.825±0.78 5.751±4.46 12.569±7.79 18.525±6.29
ENSMUST00000127740 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.369±0.00
ENSMUST00000138505 2.763±0.00 16.169±2.11 3.331±0.83 N/A 2.932±0.31 N/A 5.608±0.00 2.999±0.00 5.954±0.00 N/A N/A 7.613±0.00 N/A 27.008±0.00
ENSMUST00000149394 N/A 8.889±1.23 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000150338 N/A N/A N/A 5.683±0.00 N/A N/A N/A 0.994±0.00 N/A 1.894±0.00 N/A 3.169±1.66 6.457±0.50 12.043±3.63

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009C CIL_00009C_0002 CGP 10:80706978-80795461
CIL_0001T8 CIL_0001T8_0002 CGP 10:80755206-80798626

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0008134 IEA transcription factor binding
GO:0016571 IDA histone methylation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0034968 IEA histone lysine methylation
GO:0042054 IDA histone methyltransferase activity
GO:0046425 IEA regulation of JAK-STAT cascade
GO:2000677 IEA regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061992 dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) protein_coding Danio_rerio
ENSG00000104885 DOT1L DOT1-like histone H3K79 methyltransferase protein_coding Homo_sapiens

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