C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DOT1-like histone H3K79 methyltransferase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000398665 DOT1L-001 ENSG00000104885 9606 + 19:2164149-2232578 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000398665
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000398665 2.647±0.00 6.469±0.00 0.744±0.00 1.285±0.83 1.792±0.46 1.470±0.88 0.950±0.81 5.290±0.00 1.403±1.02 7.162±0.00 1.560±1.30 4.329±2.16 5.859±1.79 16.602±4.71

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00009F CIL_00009F_0001 CGP 19:2096429-2164465
CIL_00009C CIL_00009C_0001 CGP 19:2100988-2232578
CIL_0001T8 CIL_0001T8_0001 CGP 19:2164149-2237704

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0008134 IPI transcription factor binding
GO:0016571 IEA histone methylation
GO:0018024 IDA:IEA histone-lysine N-methyltransferase activity
GO:0034968 IEA histone lysine methylation
GO:0042054 IEA histone methyltransferase activity
GO:0046425 IDA regulation of JAK-STAT cascade
GO:2000677 IMP regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105336 Dot1l-001 protein_coding Mus_musculus 0 4047
ENSMUST00000150338 Dot1l-003 protein_coding Mus_musculus 0 2518
ENSMUST00000127740 Dot1l-002 nonsense_mediated_decay Mus_musculus 0 2036
ENSMUST00000149394 Dot1l-004 nonsense_mediated_decay Mus_musculus 0 983
ENSDART00000089076 dot1l-201 protein_coding Danio_rerio 0 922
ENSDART00000142046 dot1l-001 protein_coding Danio_rerio 0 889
ENSMUST00000163526 Dot1l-007 retained_intron Mus_musculus 0 562
ENSMUST00000147579 Dot1l-006 retained_intron Mus_musculus 1.4013e-45 191

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