C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: v-akt murine thymoma viral oncogene homolog 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105221 AKT2 9606 - 19:40230317-40285536 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311278 AKT2-027 40233841-40265312 protein_coding
  ENST00000358335 AKT2-042 40242628-40285265 protein_coding
  ENST00000391844 AKT2-026 40233670-40285373 nonsense_mediated_decay
  ENST00000391845 AKT2-017 40235894-40240299 processed_transcript
  ENST00000392037 AKT2-014 40242574-40265547 protein_coding
  ENST00000392038 AKT2-001 40230317-40285395 protein_coding
  ENST00000416362 AKT2-010 40242577-40270769 protein_coding
  ENST00000416994 AKT2-008 40255158-40279639 protein_coding
  ENST00000423127 AKT2-007 40242616-40284822 protein_coding
  ENST00000424901 AKT2-201 40230318-40285395 protein_coding
  ENST00000427375 AKT2-011 40255244-40269589 protein_coding
  ENST00000441941 AKT2-012 40241959-40266348 protein_coding
  ENST00000452077 AKT2-005 40242573-40284954 protein_coding
  ENST00000456441 AKT2-006 40242653-40284951 protein_coding
  ENST00000476247 AKT2-041 40233781-40236071 protein_coding
  ENST00000476266 AKT2-002 40232337-40243302 retained_intron
  ENST00000480878 AKT2-037 40236024-40240110 processed_transcript
  ENST00000483166 AKT2-003 40232335-40239500 retained_intron
  ENST00000486368 AKT2-033 40242040-40280832 protein_coding
  ENST00000486647 AKT2-023 40236024-40237307 processed_transcript
  ENST00000487537 AKT2-015 40241382-40255269 retained_intron
  ENST00000489375 AKT2-019 40233668-40236031 nonsense_mediated_decay
  ENST00000491778 AKT2-034 40240070-40256963 nonsense_mediated_decay
  ENST00000492463 AKT2-013 40238942-40266317 nonsense_mediated_decay
  ENST00000496089 AKT2-022 40233755-40238066 retained_intron
  ENST00000497948 AKT2-021 40233879-40235958 protein_coding
  ENST00000498350 AKT2-009 40268642-40279224 processed_transcript
  ENST00000537834 AKT2-016 40239590-40279330 retained_intron
  ENST00000578123 AKT2-029 40242584-40285536 protein_coding
  ENST00000578282 AKT2-040 40236024-40239005 retained_intron
  ENST00000578310 AKT2-036 40236302-40242011 protein_coding
  ENST00000578615 AKT2-035 40235102-40242608 protein_coding
  ENST00000578975 AKT2-043 40240791-40244127 retained_intron
  ENST00000579047 AKT2-025 40234498-40285342 protein_coding
  ENST00000579345 AKT2-039 40236024-40239132 retained_intron
  ENST00000580747 AKT2-032 40255158-40266359 protein_coding
  ENST00000580878 AKT2-038 40236032-40239269 retained_intron
  ENST00000581582 AKT2-031 40282248-40283165 processed_transcript
  ENST00000583859 AKT2-030 40242677-40284949 protein_coding
  ENST00000584288 AKT2-024 40233821-40285342 nonsense_mediated_decay
  ENST00000596634 AKT2-045 40242056-40285092 protein_coding
  ENST00000601166 AKT2-044 40237990-40255177 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311278ENST00000391844ENST00000392038ENST00000424901ENST00000476266ENST00000483166ENST00000487537ENST00000578615ENST00000579345ENST00000580747ENST00000584288
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311278 N/A N/A N/A N/A N/A N/A N/A N/A 13.214±0.00 N/A N/A N/A N/A N/A
ENST00000391844 N/A N/A 2.015±0.00 N/A 28.896±0.00 N/A 11.421±0.00 2.342±0.00 N/A 9.048±0.00 5.329±0.00 27.099±0.00 N/A N/A
ENST00000392038 2.841±0.00 3.934±0.00 N/A 1.964±0.00 8.295±0.00 3.466±0.00 0.537±0.00 2.715±2.02 N/A N/A N/A 8.996±0.56 2.544±0.62 6.569±1.42
ENST00000424901 2.556±0.00 N/A N/A N/A N/A N/A N/A N/A 1.836±0.82 N/A N/A N/A N/A N/A
ENST00000476266 11.030±0.00 8.780±0.00 1.967±0.00 N/A 15.746±13.81 7.602±0.00 1.084±0.00 6.066±3.33 N/A N/A 4.202±0.00 18.284±4.79 9.577±0.00 11.261±3.71
ENST00000483166 N/A N/A N/A 1.080±0.00 1.404±0.00 0.980±0.00 N/A 2.412±1.42 1.189±0.00 2.909±0.00 N/A 3.718±2.07 N/A 5.368±0.00
ENST00000487537 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.112±0.00 N/A N/A N/A N/A
ENST00000578615 N/A N/A N/A N/A N/A 4.744±0.00 N/A N/A N/A 2.474±0.00 N/A N/A N/A N/A
ENST00000579345 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.877±0.00 N/A
ENST00000580747 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 16.394±0.00 N/A N/A N/A
ENST00000584288 12.324±0.00 12.112±0.00 N/A N/A 23.029±0.00 13.483±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0005886 ISS plasma membrane
GO:0005938 ISS cell cortex
GO:0005978 IEA glycogen biosynthetic process
GO:0006006 IEA glucose metabolic process
GO:0006417 IEA regulation of translation
GO:0006464 TAS cellular protein modification process
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0008286 IMP insulin receptor signaling pathway
GO:0008643 IEA carbohydrate transport
GO:0010748 IMP negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 IMP positive regulation of glucose metabolic process
GO:0016301 TAS kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030334 TAS regulation of cell migration
GO:0031340 ISS positive regulation of vesicle fusion
GO:0032000 IMP positive regulation of fatty acid beta-oxidation
GO:0032287 IEA peripheral nervous system myelin maintenance
GO:0032587 ISS ruffle membrane
GO:0032859 IEA activation of Ral GTPase activity
GO:0032869 IMP cellular response to insulin stimulus
GO:0045444 TAS fat cell differentiation
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0046326 IMP positive regulation of glucose import
GO:0060644 TAS mammary gland epithelial cell differentiation
GO:0061024 TAS membrane organization
GO:0065002 ISS intracellular protein transmembrane transport
GO:0071156 TAS regulation of cell cycle arrest
GO:0072659 IEA protein localization to plasma membrane
GO:0090314 ISS positive regulation of protein targeting to membrane
GO:2000147 IMP positive regulation of cell motility
GO:2001275 IEA positive regulation of glucose import in response to insulin stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011219 akt2 v-akt murine thymoma viral oncogene homolog 2 protein_coding Danio_rerio
ENSDARG00000026797 akt2l v-akt murine thymoma viral oncogene homolog 2, like protein_coding Danio_rerio
ENSMUSG00000004056 Akt2 thymoma viral proto-oncogene 2 protein_coding Mus_musculus

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