C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105329 TGFB1 9606 - 19:41301587-41353911 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000221930 TGFB1-001 41330323-41353911 protein_coding
  ENST00000597453 TGFB1-002 41342021-41348341 retained_intron
  ENST00000598758 TGFB1-004 41301587-41342030 protein_coding
  ENST00000600196 TGFB1-003 41332055-41344840 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonLungOvaryPlacentaTestisENST00000221930ENST00000598758
Transcript ID Bladder Breast Colon Lung Ovary Placenta Testis
ENST00000221930 2.823±0.00 19.971±0.00 23.032±0.00 3.527±0.00 45.467±10.33 59.302±10.62 N/A
ENST00000598758 N/A N/A N/A N/A 55.713±0.00 N/A 121.620±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TR CIL_0008TR_0001 VISTA 19:41131081-41732986
CIL_00078X CIL_00078X_0001 CGP 19:41301587-41353911

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IDA protein import into nucleus, translocation
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IMP MAPK cascade
GO:0001657 IEA ureteric bud development
GO:0001666 IEA response to hypoxia
GO:0001763 IEA morphogenesis of a branching structure
GO:0001775 IEA cell activation
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001948 IPI glycoprotein binding
GO:0002028 IEA regulation of sodium ion transport
GO:0002062 IDA chondrocyte differentiation
GO:0002244 IDA hematopoietic progenitor cell differentiation
GO:0002248 TAS connective tissue replacement involved in inflammatory response wound healing
GO:0002460 IEA adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513 IEA tolerance induction to self antigen
GO:0002576 TAS platelet degranulation
GO:0003823 IPI antigen binding
GO:0005114 IDA type II transforming growth factor beta receptor binding
GO:0005125 TAS cytokine activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 ISS proteinaceous extracellular matrix
GO:0005615 IDA:IEA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0005902 IDA microvillus
GO:0006468 ISS protein phosphorylation
GO:0006611 IDA protein export from nucleus
GO:0006754 IDA ATP biosynthetic process
GO:0006796 IDA phosphate-containing compound metabolic process
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006954 IDA inflammatory response
GO:0007050 IDA cell cycle arrest
GO:0007093 IDA mitotic cell cycle checkpoint
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007182 IDA common-partner SMAD protein phosphorylation
GO:0007183 IDA SMAD protein complex assembly
GO:0007184 IDA SMAD protein import into nucleus
GO:0007406 IEA negative regulation of neuroblast proliferation
GO:0007435 IEP salivary gland morphogenesis
GO:0007492 IEA endoderm development
GO:0007565 IEA female pregnancy
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008156 IMP negative regulation of DNA replication
GO:0008283 IEA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008354 IEA germ cell migration
GO:0009314 IEA response to radiation
GO:0009611 IEP response to wounding
GO:0009749 IEA response to glucose
GO:0009817 IEA defense response to fungus, incompatible interaction
GO:0009986 IMP cell surface
GO:0010033 IEA response to organic substance
GO:0010575 TAS positive regulation vascular endothelial growth factor production
GO:0010628 IDA positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010716 IC negative regulation of extracellular matrix disassembly
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010742 IC macrophage derived foam cell differentiation
GO:0010763 IDA positive regulation of fibroblast migration
GO:0010800 IDA positive regulation of peptidyl-threonine phosphorylation
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 IDA negative regulation of macrophage cytokine production
GO:0014070 IEA response to organic cyclic compound
GO:0016049 IEA cell growth
GO:0016202 ISS regulation of striated muscle tissue development
GO:0017015 IDA regulation of transforming growth factor beta receptor signaling pathway
GO:0019048 TAS modulation by virus of host morphology or physiology
GO:0019049 IDA evasion or tolerance of host defenses by virus
GO:0019058 TAS viral life cycle
GO:0019899 IPI enzyme binding
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0030141 IEA secretory granule
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030214 IDA hyaluronan catabolic process
GO:0030217 IEA T cell differentiation
GO:0030279 IEA negative regulation of ossification
GO:0030308 IDA negative regulation of cell growth
GO:0030334 TAS regulation of cell migration
GO:0030335 IDA positive regulation of cell migration
GO:0030424 IEA axon
GO:0030501 IEP positive regulation of bone mineralization
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 IEA mammary gland development
GO:0031012 IEA extracellular matrix
GO:0031065 IEA positive regulation of histone deacetylation
GO:0031093 TAS platelet alpha granule lumen
GO:0031100 IEA organ regeneration
GO:0031334 IDA positive regulation of protein complex assembly
GO:0031536 IEA positive regulation of exit from mitosis
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032270 IDA positive regulation of cellular protein metabolic process
GO:0032355 IDA response to estradiol
GO:0032570 IDA response to progesterone
GO:0032740 IDA positive regulation of interleukin-17 production
GO:0032801 IDA receptor catabolic process
GO:0032930 IDA positive regulation of superoxide anion generation
GO:0032943 IEA mononuclear cell proliferation
GO:0032967 IMP positive regulation of collagen biosynthetic process
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0033280 IEA response to vitamin D
GO:0034616 IEA response to laminar fluid shear stress
GO:0035066 IEA positive regulation of histone acetylation
GO:0035307 IDA positive regulation of protein dephosphorylation
GO:0040007 IEA growth
GO:0042060 IEA wound healing
GO:0042110 IEA T cell activation
GO:0042127 IEA regulation of cell proliferation
GO:0042130 IEA negative regulation of T cell proliferation
GO:0042306 ISS regulation of protein import into nucleus
GO:0042307 IDA positive regulation of protein import into nucleus
GO:0042482 IEA positive regulation of odontogenesis
GO:0042493 IEA response to drug
GO:0042552 IEA myelination
GO:0042803 IEA protein homodimerization activity
GO:0043011 IEA myeloid dendritic cell differentiation
GO:0043025 IEA neuronal cell body
GO:0043029 IEA T cell homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043491 IMP protein kinase B signaling
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0043537 IDA negative regulation of blood vessel endothelial cell migration
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 IEP ossification involved in bone remodeling
GO:0045066 IEA regulatory T cell differentiation
GO:0045216 IDA cell-cell junction organization
GO:0045599 IDA negative regulation of fat cell differentiation
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045786 IDA negative regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046732 TAS active induction of host immune response by virus
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0048298 IDA positive regulation of isotype switching to IgA isotypes
GO:0048535 ISS lymph node development
GO:0048565 IEA digestive tract development
GO:0048642 IDA negative regulation of skeletal muscle tissue development
GO:0048839 IEA inner ear development
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050714 IDA positive regulation of protein secretion
GO:0050765 IEA negative regulation of phagocytosis
GO:0050777 IEA negative regulation of immune response
GO:0050868 IEA negative regulation of T cell activation
GO:0050921 IDA positive regulation of chemotaxis
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051098 ISS regulation of binding
GO:0051101 ISS regulation of DNA binding
GO:0051152 IEA positive regulation of smooth muscle cell differentiation
GO:0051280 IEA negative regulation of release of sequestered calcium ion into cytosol
GO:0051781 IEA positive regulation of cell division
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060312 IC regulation of blood vessel remodeling
GO:0060325 IEA face morphogenesis
GO:0060364 IEA frontal suture morphogenesis
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060391 IDA positive regulation of SMAD protein import into nucleus
GO:0060744 IEA mammary gland branching involved in thelarche
GO:0060751 IEA branch elongation involved in mammary gland duct branching
GO:0060762 IEA regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 IEA regulation of cartilage development
GO:0070306 IEA lens fiber cell differentiation
GO:0070723 IDA response to cholesterol
GO:0071158 IEA positive regulation of cell cycle arrest
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0072562 IDA blood microparticle
GO:0085029 IDA extracellular matrix assembly
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:1900126 IDA negative regulation of hyaluronan biosynthetic process
GO:1900182 IEA positive regulation of protein localization to nucleus
GO:1901203 IC positive regulation of extracellular matrix assembly
GO:1901666 IDA positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000249 IEA regulation of actin cytoskeleton reorganization
GO:2000628 IDA regulation of miRNA metabolic process
GO:2000679 IDA positive regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034895 tgfb1b transforming growth factor, beta 1b protein_coding Danio_rerio
ENSDARG00000041502 tgfb1a transforming growth factor, beta 1a protein_coding Danio_rerio
ENSMUSG00000002603 Tgfb1 transforming growth factor, beta 1 protein_coding Mus_musculus

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