C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002603 Tgfb1 10090 + 7:25687002-25705077 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002678 Tgfb1-001 25687002-25705077 protein_coding
  ENSMUST00000169009 Tgfb1-003 25688927-25697213 nonsense_mediated_decay
  ENSMUST00000171757 Tgfb1-002 25692418-25697174 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002678ENSMUST00000169009ENSMUST00000171757
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002678 15.242±3.61 17.682±2.15 10.063±1.87 1.713±0.44 28.483±13.52 9.371±2.15 7.312±2.23 8.267±0.94 8.356±7.35 26.007±1.41 1.587±0.78 17.351±2.83 9.424±2.46 2.161±0.94
ENSMUST00000169009 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.604±0.00 0.482±0.00
ENSMUST00000171757 N/A N/A N/A 4.329±0.00 N/A N/A N/A N/A N/A N/A N/A 40.803±0.00 39.703±1.13 1.951±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TR CIL_0008TR_0002 VISTA 7:25324415-25925712
CIL_0006US CIL_0006US_0002 CGP 7:25681158-25705077
CIL_00078X CIL_00078X_0002 CGP 7:25687002-25719088

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 ISS protein import into nucleus, translocation
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 ISS MAPK cascade
GO:0001501 TAS skeletal system development
GO:0001657 IEP ureteric bud development
GO:0001666 IEA response to hypoxia
GO:0001763 IEA morphogenesis of a branching structure
GO:0001775 IDA cell activation
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001933 ISS negative regulation of protein phosphorylation
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001948 IEA glycoprotein binding
GO:0002028 IDA regulation of sodium ion transport
GO:0002062 ISS chondrocyte differentiation
GO:0002244 ISS hematopoietic progenitor cell differentiation
GO:0002460 IDA adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513 IMP tolerance induction to self antigen
GO:0003823 IEA antigen binding
GO:0005114 ISS type II transforming growth factor beta receptor binding
GO:0005160 TAS transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005578 IDA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005902 ISS microvillus
GO:0006468 IDA protein phosphorylation
GO:0006611 ISS protein export from nucleus
GO:0006754 ISS ATP biosynthetic process
GO:0006796 ISS phosphate-containing compound metabolic process
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006952 TAS defense response
GO:0006954 IMP inflammatory response
GO:0007050 ISS cell cycle arrest
GO:0007093 ISS mitotic cell cycle checkpoint
GO:0007173 ISS epidermal growth factor receptor signaling pathway
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007182 ISS common-partner SMAD protein phosphorylation
GO:0007183 ISS SMAD protein complex assembly
GO:0007184 ISS SMAD protein import into nucleus
GO:0007406 IEA negative regulation of neuroblast proliferation
GO:0007435 IEA salivary gland morphogenesis
GO:0007492 IDA endoderm development
GO:0007519 TAS skeletal muscle tissue development
GO:0007565 IEA female pregnancy
GO:0007568 IEA aging
GO:0008083 IEA growth factor activity
GO:0008156 ISS negative regulation of DNA replication
GO:0008283 IDA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008354 IDA germ cell migration
GO:0009314 IEA response to radiation
GO:0009611 IEA response to wounding
GO:0009749 IEA response to glucose
GO:0009817 IEA defense response to fungus, incompatible interaction
GO:0009887 TAS organ morphogenesis
GO:0009986 ISS cell surface
GO:0010033 IEA response to organic substance
GO:0010628 IDA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010763 ISS positive regulation of fibroblast migration
GO:0010800 ISS positive regulation of peptidyl-threonine phosphorylation
GO:0010862 ISS positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 IEA negative regulation of macrophage cytokine production
GO:0014070 IEA response to organic cyclic compound
GO:0016049 IEA cell growth
GO:0016202 IDA regulation of striated muscle tissue development
GO:0017015 ISS regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 ISS evasion or tolerance of host defenses by virus
GO:0019899 IEA enzyme binding
GO:0022408 ISS negative regulation of cell-cell adhesion
GO:0030141 IEA secretory granule
GO:0030214 ISS hyaluronan catabolic process
GO:0030217 IMP T cell differentiation
GO:0030279 IDA negative regulation of ossification
GO:0030308 IDA negative regulation of cell growth
GO:0030335 ISS positive regulation of cell migration
GO:0030424 IEA axon
GO:0030501 IEA positive regulation of bone mineralization
GO:0030879 IDA mammary gland development
GO:0031012 IDA extracellular matrix
GO:0031065 IDA positive regulation of histone deacetylation
GO:0031100 IEA organ regeneration
GO:0031334 ISS positive regulation of protein complex assembly
GO:0031536 IEA positive regulation of exit from mitosis
GO:0031663 ISS lipopolysaccharide-mediated signaling pathway
GO:0032270 ISS positive regulation of cellular protein metabolic process
GO:0032355 ISS response to estradiol
GO:0032570 ISS response to progesterone
GO:0032740 IDA positive regulation of interleukin-17 production
GO:0032801 ISS receptor catabolic process
GO:0032930 ISS positive regulation of superoxide anion generation
GO:0032943 IMP mononuclear cell proliferation
GO:0032967 IDA positive regulation of collagen biosynthetic process
GO:0033138 ISS positive regulation of peptidyl-serine phosphorylation
GO:0033280 IEA response to vitamin D
GO:0034616 IEA response to laminar fluid shear stress
GO:0035066 IDA positive regulation of histone acetylation
GO:0035307 ISS positive regulation of protein dephosphorylation
GO:0042060 IEA wound healing
GO:0042110 IMP T cell activation
GO:0042127 IDA regulation of cell proliferation
GO:0042130 IMP negative regulation of T cell proliferation
GO:0042306 IDA regulation of protein import into nucleus
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042482 IDA positive regulation of odontogenesis
GO:0042493 IEA response to drug
GO:0042552 IEA myelination
GO:0042803 IEA protein homodimerization activity
GO:0043011 IMP myeloid dendritic cell differentiation
GO:0043025 IEA neuronal cell body
GO:0043029 IMP T cell homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043491 ISS protein kinase B signaling
GO:0043536 ISS positive regulation of blood vessel endothelial cell migration
GO:0043537 ISS negative regulation of blood vessel endothelial cell migration
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 IEA ossification involved in bone remodeling
GO:0045066 IDA regulatory T cell differentiation
GO:0045216 ISS cell-cell junction organization
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045662 ISS negative regulation of myoblast differentiation
GO:0045786 ISS negative regulation of cell cycle
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045930 ISS negative regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0048298 ISO positive regulation of isotype switching to IgA isotypes
GO:0048535 IMP lymph node development
GO:0048565 IEA digestive tract development
GO:0048642 ISS negative regulation of skeletal muscle tissue development
GO:0048839 IEA inner ear development
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0050714 ISS positive regulation of protein secretion
GO:0050765 IEA negative regulation of phagocytosis
GO:0050777 IEA negative regulation of immune response
GO:0050868 IMP negative regulation of T cell activation
GO:0050921 ISS positive regulation of chemotaxis
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051098 IDA regulation of binding
GO:0051101 IDA regulation of DNA binding
GO:0051152 ISO positive regulation of smooth muscle cell differentiation
GO:0051280 IEA negative regulation of release of sequestered calcium ion into cytosol
GO:0051781 IEA positive regulation of cell division
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0060325 IEP face morphogenesis
GO:0060364 IEA frontal suture morphogenesis
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060391 IEA positive regulation of SMAD protein import into nucleus
GO:0060744 IMP mammary gland branching involved in thelarche
GO:0060751 IMP branch elongation involved in mammary gland duct branching
GO:0060762 IGI regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 IDA regulation of cartilage development
GO:0070306 IMP lens fiber cell differentiation
GO:0070723 ISS response to cholesterol
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071407 ISS cellular response to organic cyclic compound
GO:0071549 IEA cellular response to dexamethasone stimulus
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0072562 IEA blood microparticle
GO:0085029 IDA extracellular matrix assembly
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis
GO:0097191 ISS extrinsic apoptotic signaling pathway
GO:1900126 ISS negative regulation of hyaluronan biosynthetic process
GO:1900182 IGI positive regulation of protein localization to nucleus
GO:1901666 ISS positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000249 IGI regulation of actin cytoskeleton reorganization
GO:2000628 IEA regulation of miRNA metabolic process
GO:2000679 ISS positive regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034895 tgfb1b transforming growth factor, beta 1b protein_coding Danio_rerio
ENSDARG00000041502 tgfb1a transforming growth factor, beta 1a protein_coding Danio_rerio
ENSG00000105329 TGFB1 transforming growth factor, beta 1 protein_coding Homo_sapiens

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